无痛分娩中罗哌卡因与左旋布比卡因的镇痛效果和安全性比较

Analgesic efficacy and safety comparison of ropivacaine and levobupivacaine in painless childbirth

目的对比分析无痛分娩中罗哌卡因与左旋布比卡因的镇痛效果和安全性。方法自愿要求无痛分娩的产妇64例,随机分为Ⅰ组(罗哌卡因+芬太尼)和Ⅱ组(左旋布比卡因+芬太尼)各32例,对比分析两组的不同产程镇痛VAS评分及不良反应情况。结果Ⅰ组的产妇在不同产程的疼痛程度明显减轻,且VAS评分明显低于Ⅱ组(P<0.05);产后两组产妇出现恶心、呕吐及头晕等不良反应和排气时间差异不显著。结论无痛分娩中罗哌卡因与左旋布比卡因的安全性是一致的,但罗哌卡因的镇痛效果明显优于左旋布比卡因,但仍需进一步扩大样本数进行深入研究。

Objective To compare and analyze the analgesic efficacy and safety of ropivacaine and levobupivacaine in painless childbirth. Methods All 64 patients admitted to voluntary maternal painless labor required were randomly divided into group Ⅰ （ropivacaine ＋ fentanyl） and Group Ⅱ （levobupivacaine ＋ fentanyl） of the 32 cases, and different labor pains VAS score and adverse reaction were comparative analysed between two group. Results The pain degree of Ⅰ group was reduced significantly in different production process, and the VAS score was significantly lower than Group Ⅱ （P〈0.05）. There were no significant difference after postpartum in maternal nausea, vomiting, dizziness, and the exhaust time between Group Ⅰand Group Ⅱ （P〉0.05）. Conclusion The security is the same in painless childbirth of ropivacaine and levobupivacaine. But the analgesic effect of ropivacaine was significantly better than levobupivacaine, and further study demands expand the number of samples