药源性双硫仑样反应30例临床分析

Clinical analysis of drug-induced disulfiram-like reaction:on 30 cases report

目的分析药源性双硫仑样反应的临床特点。方法对30例药源性双硫仑样反应患者的用药情况、临床症状及治疗转归进行回顾性分析。结果本组产生药源性双流仑样反应的药品依次为头孢唑林、头孢曲松、头孢哌酮舒巴坦、头孢噻肟、甲硝唑;有呼吸、循环和神经系统临床表现。28例患者经急诊抢救成功并好转出院;2例年龄较大并伴有慢性病者收住院,经综合治疗均好转出院。结论药源性双硫仑样反应临床表现多样,易误诊。

Objective To analyze the clinical features of drug-induced disulfiram-like reaction.Methods Retrospectively analyzed the drug situation,clinical symptoms and treatment outcomes of 30 cases of drug-induced disulfiram-like drug reactions.Results The raw of drugs induced disulfiram-like reaction were cefazolin sodium,ceftriaxone,cefoperazone sulbactam,cefotaxime sodium and metronidazole.Clinical symoptoms included respiratory,circulatory and nervous system.28 cases patients improved after successful emergency treatment and discharged from hospital;2 cases older associated with chronic diseases were admitted into the hospital,improved and discharged from hospital after combined treatment.Conclusion Drug-induced disulfiram-like reaction has diverse clinical manifestations,is often been misdiagnosed.