摘要
目的观察2型糖尿病及合并代谢综合征危险因素患者中氧化应激指标尿8-异前列腺素F2α水平。方法选择60例2型糖尿病患者,根据是否有合并代谢综合征危险因素分为单纯2型糖尿病组22例和合并代谢综合征危险因素组38例,同时选取健康查体者作为正常对照组30例。用ELISA法检测3组尿8-异前列腺素F2α水平。结果与正常对照组相比,单纯2型糖尿病组及2型糖尿病合并代谢综合征危险因素组尿8-异前列腺素F2α水平显著升高,差异有统计学意义(P<0.01);与单纯2型糖尿病组相比,2型糖尿病合并代谢综合征危险因素组尿8-异前列腺素F2α水平明显提高,差异有统计学意义(P<0.05)。结论单纯2型糖尿病患者存在着氧化应激,2型糖尿病合并代谢综合征危险因素患者氧化应激水平增高,提示临床上使用抗氧化药物可预防其综合征的发生。
Objective To observe the urine 8-different prostaglandin F2α level of patient with type 2 diabetes and combined with metabolic syndrome risk factor.Methods 60 cases patients with type 2 diabetes,according to whether with the metabolic syndrome risk factor into simple type 2 diabetes group（22 cases） and combined with metabolic syndrome risk factor group（38 cases）,and selected 30 cases kindergarden person as normal control group.With ELISA method to detect urine 8-different prostaglandin F2α level of three groups.Results Compared with normal control group,the urine 8-different prostaglandin F2α level of simple type 2 diabetes group and combined with metabolic syndrome risk factor group significantly increased,the difference were statistically significant（P0.01）;Compared with simple type 2 diabetes group,the urine 8-different prostaglandin F2α level of combined with metabolic syndrome risk factor group obviously improved,the difference was statistically significant（P0.05）.Conclusion Simple type 2 diabetes patient exist oxidative stress,the oxidative stress level of patient with type 2 diabetes patient combined with metabolic syndrome risk factor increase,indicating that the clinical use of antioxidant drug can prevent the happening of the syndrome.
出处
《临床合理用药杂志》
2012年第4期20-21,共2页
Chinese Journal of Clinical Rational Drug Use
