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Mindin：糖尿病肾病足细胞损伤的新型标记物 被引量：4

Mindin：a new biomarker of podocyte injury in diabetic nephropathy
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摘要 Mindin（也称spondin-2）是一个高度同源的细胞外基质蛋白，既往研究发现，mindin可作为病原微生物模式识别分子和整合素配体参与非特异性和特异性免疫反应，并有促进神经元的黏附和生长的功能。近年研究发现，mindin可由损伤的足细胞合成，其参与糖尿病肾病的发生、发展，并与糖尿病足细胞损伤密切相关。与健康人相比，2型糖尿病患者的尿液mindin表达增加，并能反映糖尿病。肾病严重程度。因此，mindin有望成为糖尿病肾病足细胞损伤新标记物。 Mindin （ also known as spondin-2） is a highly conserved extracellular matrix protein. Previous evidences indicated that mindin, as a pattern of recognition moleculers for microbial pathogens and an integrin ligand, participated in non-specific and specific immunoreactions, and promoted the adhesion and outgrowth of neurons. Recent researches found that mindin was produced by the impaired podocytes, participated in the progression of diabetic nephropathy, and was related to podocyte injury. Compared with healthy populations, the mindin expression from urine was increased in patients with type 2 diabetes, and can reflect the severity of diabetic nephropathy. Therefore, mindin is expected to be a new biomarker of podocyte injury in diabetic nephropathy.
作者 廖钰 夏宁
机构地区 广西医科大学第一附属医院代谢糖尿病中心
出处 《国际内分泌代谢杂志》 北大核心 2012年第1期18-20,共3页 International Journal of Endocrinology and Metabolism
基金 广西地方性高发疾病防治研究重点实验室基金资助项目（0842009-K10）
关键词 Mindin 糖尿病肾病 足细胞损伤 糖尿病 Mindin Diabetic nephropathy Podoeyte injury Diabetes mellitus
分类号 R587.2 [医药卫生—内分泌]
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参考文献17

  • 1Jia W, Li H, He YW. Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses. J Immunol,2008,180:6255-6261.
  • 2He YW,Li H ,Zhang J ,et al. The extraceUular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol,2004 ,5 :88-97.
  • 3Li Y, Cao C,Jia W, et al. Structure of the F-spondin domain of mindin, an integrln ligand and pattern recognition molecule. EMBO J ,2009,28:286-297.
  • 4Murakoshi M, Tanimoto M, Gohda T, et al. Mindin : a novel marker for podocyte injury in diabetic nephropathy. Nephrol Dial Transplant,2011,26:2153-2160.
  • 5Jia W, Li H, He YW. Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses. J Immunol,2008, 180 : 6255 -6261.
  • 6Jia W, Li H, He YW. The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood ,2005,106:3854-3859.
  • 7Li H, Oliver T, Jia W, et al. Efficient dendritic cell priming of T lymphocytes depends on the extraecllular matrix protein mindin. EMBO J,2006,25 : 4097-4107.
  • 8Li Z, Garantziotis S, Jia W, et al. The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. J Leukoc Bio1,2009,85 : 124-131.
  • 9Feinstein Y, Klar A. The neuronal class 2 TSR proteins F-spondin and Mindin : a small family with divergent biological activities. Int J Biochem Cell Biol,2004,36:975-980.
  • 10Li JJ, Kwak S J, Jung DS, et al. Podocyte biology in diabetic nephropathy. Kidney Int Suppl,2007,106 : S36-S42.

同被引文献29

  • 1Cheung N,Wong TY. Diabetic retinopathy and systemic vascular complications[J]. Prog Retin Eye Res,2008,27(2) : 161-176.
  • 2Chavers BM,Bilous RW,Ellis EN,et al. Glomerular lesions and urinaryalbumin excretion in type I diabetes without overt protein- uria[J]. N Engl J Med, 1989,320(15) :966-970.
  • 3Murakoshi M,Tanimoto M, Gohda T, et al. Mindin : a novel marker for podocyte injury in diabetic nephropathy [J]. Nephrol Dial Transplant, 2011,26(7) :2153-2160.
  • 4Nomnha IL,Fujihara CK,Zata R. The inflammatory component in progressive renal disease-are interventions possible? [J]. Nephrol Dial Transplant, 2002,17(3) :363-368.
  • 5Murakoshi Maki,Tanimoto Mitsuo,Gohda Tomohito,Hagiwara Shinji,Takagi Miyuki,Horikoshi Satoshi,Tomino Yasuhiko.Mindin: a novel marker for podocyte injury in diabetic nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . 2010
  • 6Okada Tatsuo,Wada Jun,Hida Kazuyuki,Eguchi Jun,Hashimoto Izumi,Baba Masako,Yasuhara Akihiro,Shikata Kenichi,Makino Hirofumi.Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. Diabetes . 2006
  • 7Pawluczyk Izabella Z A,Yang Bin,Patel Samita R,Saleem Moin A,Topham Peter S.Low-level C-reactive protein levels exert cytoprotective actions on human podocytes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association . 2011
  • 8Jia W,Li H,He YW.Pattern recognition molecule mindin promotes intranasal clearance ofinfluenza viruses. J Immunol . 2008
  • 9Hara M,Yamagata K,Tomino Y,et al.Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes:establishment of a highly sensitive ELISA to detect urinary podocalyxin[J].Diabetologia,2012,55(11):2913-2919.
  • 10Wilkinson CP,Ferris FL,Klein RE,et al.Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales[J].Ophthalmology,2003,110(9):1677-1682.

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国际内分泌代谢杂志
2012年 第1期

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