结缔组织生长因子与糖尿病肾脏纤维化及其基因干预

Connective tissue growth factor,diabetic renal fibrosis and its gene interference

结缔组织生长因子（CTGF）是组织纤维化的关键介质。多种因素包括高糖环境、一些特异的生长因子以及环境因素和生物机械因素都能刺激CTGF的合成。糖尿病。肾病（DN）及其他进展性肾脏疾病的晚期表现为肾脏纤维化。CTGF通过自身或介导其他因子的作用引起肾脏细胞外基质（ECM）沉积，进而进展为肾小球和肾间质纤维化。RNA干扰是近年出现的一种新的抑制基因表达的技术方法。其具有特异、高效、易操作等优点，已成为研究基因沉默在临床应用的前沿。靶向干预CTGF的表达可预防和治疗DN肾脏纤维化。

Connective tissue growth factor （CTGF） is a key mediator of tissue fibrosis. Various factors including hyperglycemia, some specific growth factors, surrounding factor, and organism-mechanical factor, can stimulate the synthesis of CTGF. The manifestation of advanced diabetic nephropathy （DN）, and other progressive kidney diseases is kidney fibrosis. CTGF by itself or through other cytokins, promote the deposit of extra-cellular matrix（ECM） in kidney, and then result in the fibrosis of renal glomerulus and interstitium. RNA interference （RNAi） is a new technique of gene inhibition with high specificity and efficiency, and easy-to-manipulate. Targeting and intervening the expression of CTGF can treat and prevent renal fibrosis of DN.