摘要
趋化因子CXCL9又称Mig,是干扰素(IFN)-γ诱导的单核因子,是CXC亚族的一员,主要趋化淋巴细胞,在糖尿病。肾病的发生、发展中起重要作用。它可能通过:(1)直接诱导肾脏系膜细胞增殖而加重肾脏损伤。(2)趋化辅助性T淋巴细胞1型在炎性反应组织聚集。(3)诱导炎性反应因子的级联反应。(4)损伤足突细胞导致蛋白尿等机制而起作用。因此,对CXCL9及其受体的研究可能为糖尿病肾病的治疗提供新的思路。
Chemokines CXCL9/Mig,known as monokine induced by interferon-γ(IFN-3,), belongs to the subfamily of ehemotactic cytokines CXC, a chemoattraetant for activated T lymphocytes. CXCL9 may play a role in the development and progression of diabetic nephropathy (DN). The mechanisms may include: ( 1 ) directly inducing the proliferation of mesangial cells, and aggravating the renal injury, ( 2 ) attracting auxiliary T lymphocytes to tissues with inflammatory reactions, ( 3 ) inducing the inflammatory cascade, and (4) leading to podoeyte injury and proteinuria. Therefore, studies on CXCL9 and its receptors can provide new clues for the treatment of DN.
出处
《国际内分泌代谢杂志》
北大核心
2012年第1期24-25,31,共3页
International Journal of Endocrinology and Metabolism
基金
辽宁省医学高峰建设工程重点科研资助项目(200938)
辽宁省高等学校科研项目计划(2008800)