磁致热疗肿瘤用磁场发生装置的研制

Design of sine wave magnetic device for magnetic-induced tumor hyperthermia

目的:设计一种磁感应致热疗肿瘤用的正弦波形磁场发生装置。方法:电路采用555时基芯片为核心,利用单运放与RC组成的电路,将脉冲波形信号转换为正弦波形信号,然后通过放大电路进行电流放大,加负载线圈后产生所需磁场。结果:所研制的磁场发生装置可调节产生频率范围为50～150 kHz的正弦波形磁场,加入微量纳米磁性粒子集合体后发生磁致产热现象。结论:所研制的磁场发生装置具有成本低,精度高,性能稳定,参数调整方便等优点,为研究磁致热疗肿瘤提供必要的手段。

Objective： To design a magnetic field generator for magnetic induction hyperthermia.Methods： The equipment used the 555 chip as the core and use of amplifier and RC oscillator circuit changing the pulse pattern to the sine wave,then amplified the current,and when we added a external coil it generate the required magnetic field.Results： The instrument could produce sine wave magnetic field with a frequency of 50kHz-150kHz,and the magnetic-nano particles could produce heat.Conclusion： The circuit can heat the magnetic-nanoparticles and is of low cost and high accuracy.It is a good instrument for that tumor magnetic hyperthermia.