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FIZZ1分子通道在肺组织纤维化中的作用

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摘要 FIZZ1（found in inflammatory zone 1）是一种新发现的与炎症相关的缺氧诱导的分泌型蛋白,在肺内特异表达,具有刺激肺动脉平滑肌细胞增殖、收缩血管、刺激肌纤维母细胞分化、抑制凋亡等功能,在肺纤维化、肺动脉高压等发病中具有重要作用。目前,肺纤维化的发病率在全球呈上升趋势,且所有慢性肺疾病的晚期都存在不同程度的纤维化改变。
作者 冯一 刘升明
机构地区 暨南大学附属第一医院呼吸内科
出处 《广东医学》 CAS CSCD 北大核心 2012年第1期137-139,共3页 Guangdong Medical Journal
关键词 肺组织纤维化 FIZZ1 INFLAMMATORY 肺动脉平滑肌细胞增殖 通道 分子 肺纤维化 肺动脉高压
分类号 R135.2 [医药卫生—劳动卫生]
  • 相关文献

参考文献31

  • 1RAES G, DE BAETSELIER P, NOEL W, et al. Differential ex- pression of FIZZ1 and Yml in alternatively versus classically acti- vated macrophages[J]. J Leukoc Biol, 2002, 71(4) : 597.
  • 2HOLCOMB I N, KABAKOFF R C, CHAN B, et al. FIZZ1, a no- vel cysteine - rich - secreted protein associated with pulmonary in- flammation, defines a new gene family[ J]. EMBO J, 2000, 19 (15) : 4046 -4055.
  • 3TENG X, LI D, CHAMPION H C, et al. FIZZ1/RELMα, a no- vel hypoxia - induced mitogenic factor in lung with vasoconstrictive and angiogenic properties [ J ]. Circ Res, 2003, 92 (10) : 1065 - 1067.
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二级参考文献10

  • 1叶红,马万里,杨木兰,刘声远,王迪浔.慢性吸烟大鼠气道平滑肌大电导的钙激活钾通道和Kv1.5表达的变化(英文)[J].生理学报,2004,56(5):573-578. 被引量：10
  • 2Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A,Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ,Frantz GD, Tumas DB, Peale FV Jr, Shelton DL, Hebert CC.FIZZ1, a novel cysteine-rich secreted protein associated withpulmonary inflammation, defines a new gene family. EMBOJ 2000; 19(15): 4046-4055.
  • 3Rajala MW, Lin Y, Ranalletta M, Yang XM, Qian H, Gingerich R, Barzilai N, Scherer PE. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue. Mol Endocrinol 2002; 16(8): 1920-1930.
  • 4Gerstmayer B, Kusters D, Gebel S, Muller T, Van Miert E,Hofmann K, Bosio A. Identification of RELMganuna, a novel resistin-like molecule with a distinct expression pattern.Genomics 2003; 81(6): 588-595.
  • 5Liu T, Dhanasekaran SM, Jin H, Hu B, Tomlins SA, Chinnaiyan AM, Phan SH. FIZZ1 stimulation of myofibroblast differentiation. Am J Pathol 2004; 164(4): 1315-1326.
  • 6Liu T, Jin H, Ullenbruch M, Hu B, Hashimoto N, Moore B,Mckenzie A, Lukacs NW, Phan SH. Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. J Immunol 2004; 173(5): 3425-3431.
  • 7Raes G, Baetselier PD, Noel W, Beschin A, Brombacher F,Hassanzadeh Gh G, Differential expression of FIZZ1 and Ym 1 in alternatively versus classically activated macrophages.J Leukoc Biol 2002; 71(4): 597-602.
  • 8Teng X, Li D, Champion HC, Johns RA. FIZZ1/RELM/REL Ma, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. Circ Res 2003; 92(10): 1065-1067.
  • 9Streiter RM. Inflammatory mechanisms are not a minor component of the pathogenesis of idiopathic pulmonary fibrosis.Am J Respir Crit Care Med 2002; 165(9): 1206-1208.
  • 10Xu Y, Hua J, Mui A, O'Connor R, Grotendorst G, Khalil N.Release of biologically active TGF-betal by alveolar epithelial cells results in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2003; 285(3): L527-L539.

共引文献9

广东医学
2012年 第1期

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