大鼠单侧隔核内微量注入TRH或吗啡对痛阈及电针镇痛的影响

THE EFFECTS OF MICROINJECTION OF TRH OR MORPHINE INTO UNILATERAL NUCLEUS SEPTUM ON PAIN THRESHOLD AND ELECTROACUPUNCTURE ANALGESIA IN RATS

我组曾报道脑室注入促甲状腺素释放激素(TRH)能对抗电针镇痛,其作用机理不清。隔核与脑室紧密相邻又是前脑边缘系统的重要结构,与其他边缘系统和脑区都有着密切的联系,它具有多种生理功能。

Experiments were performed on awake rats. The pain threshold (tail flick latency. TFL) was measured with radiant heat tail-flick methed. Microinjection of thyrotropin releasing hormone (TRH 2.5μg/1μl) into septal area can increase remarkably and last 40min, but the analgesic effect can not be reversed by the opioid receptor brocker Naloxone (NAL) into the septal area; injection 10μg of Morphine into unilateral septal nucleus, the pain threshold had no obvious change;