冠状动脉易损斑块相关炎性因子的研究进展

The Research Progress of Related Inflammatory Factors on Vulnerable Plaque of Coronary Arteries Disease

炎症在动脉粥样硬化(AS)中扮演重要的角色。炎症贯穿于疾病发生、发展的各个阶段,包括易损粥样斑块形成和最终的破裂。其过程涉及许多炎性细胞,如单核细胞源性巨噬细胞、T淋巴细胞及其合成和分泌的细胞因子、趋化因子和酶。这些炎性因子导致内皮细胞活化,平滑肌细胞增殖,纤维帽基质的降解而形成易损斑块。这些有关炎性因子通过各种方法可从外周血检测到,且循环血液中的炎症因子浓度与将来的心血管事件的发生密切相关。现将易损和破裂斑块的生物标记物的最新进展进行综述。

Inflammation plays a major role in all phases of atherosclerosis.Inflammation represents a major feature throughout all stages of the disease,including vulnerable plaque formation and eventually plaque rupture.Several cells typical for the atherosclerotic plaque,like monocyte-derived macrophages and T-lymphocytes are able to produce and secrete such mediator molecules,like cytokines,chemokines,enzymes,which lead to activation of endothelial cells,proliferation of smooth muscle cells,and finally to the weakening of a vulnerable plaque by matrix degradation of its fibrous cap.These inflammatory factors can be detected from peripheral blood circulation,which are closely related to future cardiovascular events.This review will focus on current advances of biomarker in vulnerable and ruptured plaques.