急性冠脉综合征患者血尿酸升高相关因素分析

Correlation between occurrence of acute coronary syndrome and elevated blood uric acid level

目的:探讨急性冠脉综合征(ACS)患者血尿酸升高的相关因素。方法:将ACS患者78例按照血尿酸水平分为A组(血尿酸<350μmmol/L)46例、B组(血尿酸≥350μmmol/L)32例,并在门诊体检人群中选取未患急性冠脉综合征的高尿酸志愿者(血尿酸≥350μmmol/L)30例作为C组,记录各组病例的年龄、性别、吸烟史、高血压史、糖尿病史、左室射血分数(LVEF)、血肌酐(Cr)、血尿素氮(BUN)、甘油三酯(TG)、总胆固醇(CHO)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖等指标。结果:A、B两组吸烟史、Cr、BUN、TG、LVEF、CHO、HDL、LDL存在显著差异(P<0.05);B、C两组患者LVEF、CHO、HDL、LDL存在显著差异(P<0.05)。结论:吸烟史以及Cr、BUN、TG水平升高可能是急性冠脉综合征患者血尿酸升高的相关因素。

Objective： To investigate correlation between occurrence of acute coronary syndrome（ACS） and elevated blood uric acid level.Methods： A total of 78 patients of ACS were divided into group A（46 cases,serum uric acid 350μmmol/L）,group B（32 cases,serum uric acid ≥ 350μmmol/L）,according to serum uric acid levels.Thirty volunteers with high uric acid volunteers but without acute coronary syndrome（uric acid ≥ 350μmmol / L） were assigned as group C.Parameters including age,sex,smoking history,history of hypertension,diabetes mellitus,left ventricular ejection fraction（LVEF）,creatinine（Cr）,blood urea nitrogen（BUN）,triglyceride（TG）,total cholesterol（CHO）,high density lipoprotein（HDL）,low density lipoprotein（LDL）,fasting glucose were recorded and compared among the three groups.Results： There were significant differences in smoking history,and Cr,BUN,TG,LVEF,CHO,HDL,LDL levels between group A and B（P0.05）;group B and C patients showed significant difference in LVEF,CHO,HDL,LDL were significantly different（P0.05）.Conclusions： Smoking history,elevated Cr,BUN,TG levels may correlated with occurrence of acute coronary syndrome.