血管内皮损伤和血小板活化与急性冠脉综合征的相关性研究

Relation between vascular endothelial damage,platelet activation and acute coronary syndrome

目的:探讨血管内皮损伤和血小板活化与急性冠脉综合征(ACS)的相关性。方法:选择我院收治的急性冠脉综合征患者40例作为研究对象,记为研究组,35例稳定型心绞痛患者作为对照1组,并选取同期门诊体检健康志愿者35例作为对照2组。采用流式细胞仪检测CD62p、CD63、GPⅡb/Ⅲa受体复合物,采用散射比浊法测定纤维原蛋白(FIB-C),采用ELASA测定假血友病因子vWF、内皮素1(ET-1),采用酶法测定NO,采用彩色多谱勒测定内皮依赖性血管舒张功能,并作以比较。结果:(1)研究组vWF、ET-1较对照1组、对照2组明显升高,(P<0.05);NO、FMD较对照1组、对照2组明显降低(P<0.05)。(2)研究组CD62p、CD63、GPⅡb/Ⅲa受体复合物以及FIB-C等反应血小板活化功能的指标明显高于对照1组和对照2组,(P<0.05)。结论:急性冠脉综合征患者反应血管内皮损伤和血小板活化的指标发生明显变化,说明血管内皮损伤和血小板活化与急性冠脉综合征有密切关系。

Objective： To investigate the relation between vascular endothelial damage,platelet activation and acute coronary syndrome.Methods：A total of 40 patients with acute coronary syndrome served as study group,35 patients of stable angina pectoris as control group 1,and healthy volunteers in outpatient department as control group 2.CD62p,CD63,GP Ⅱ b / Ⅲ a receptor complex were determined by flow cytometry,FIB-C was determined by scattering turbidimetry,vWF and ET-1 were measured by ELASA,NO was determined by enzymic method,and endothelium-dependent vasodilation was measured by color Doppler.Results： vWF and ET-1 in study group were significantly higher than those of control group 1,control group 2（P0.05）;NO and FMD were significantly lower compared with thoses of control group 1,control group 2（P0.05）.CD62p,CD63,GP Ⅱ b / Ⅲ a receptor complex and the FIB-C in study group were significantly higher than those of control group 1 and control group 2（P0.05）.Conclusions： Indexes of vascular endothelial damage and platelet activation change significantly in acute coronary syndrome patients,indicating that vascular endothelial damage and platelet activation have a relationship with acute coronary syndrome.