高尿酸血症与心血管疾病关系的分析

Relationship between hyperuricemia and cardiovascular diseases

目的:探讨高尿酸血症与心血管疾病发生的关系。方法:以287例尿酸正常的体检人员作为对照组,439例单纯尿酸增高患者为观察组1,397例尿酸增高合并C反应蛋白增高患者为观察组2,研究3组高血压与冠心病发生率;对比分析98例原发性高血压与74例继发性高血压尿酸异常水平。结果:3组高血压、冠心病发生率比较差异均有统计学意义(P均<0.05);原发性高血压与继发性高血压尿酸异常率分别为84.7%、25.7%,差异有统计学意义(P<0.05)。结论:高尿酸血症尤其合并C反应蛋白增高与高血压、冠心病的发生率有密切的关系,高尿酸是原发性高血压的一个独立危险因素。

Objective： To investigate the relationship between hyperuricemia and cardiovascular disease.Methods：A total of 287 healthy people were enrolled as control group,439 patients with simple hyperuricemia were enrolled as observation group 1,397 patients with hyperuricemia complicated with elevated C-reactive protein as observation group 2,incidence of hypertension and coronary heart disease of the three groups were observed and compared.Besides,incidence of abnormal urine acid level was compared between 98 patients with primary hypertension and 74 cases with secondary hypertension.Results：There were significant differences in the incidence of hypertension and coronary heart disease among the three groups.Besides,incidence of abnormal urine acid level in 98 patients with primary hypertension and 74 cases with secondary hypertension was 84.6%、25.6%,respectively,showing significant difference between the two groups.Conclusions：Hyperuricemia,particularly complicated with hypertension or elevated C-reactive protein,was correlated with coronary heart disease,elevated uric acid level is an independent risk factor for the occurrence of primary hypertension.