异丙嗪对针刺镇痛的影响

EFFECTS OF PROMETHAZINE ON ACUPUNCTURE ANALGESIA

组胺H_1受体拮抗剂异丙嗪(Promethazine),即非那根(phenargan),是临床上常用的药物。在临床针刺麻醉中,普遍用为针麻的辅助药物,主要目的是镇静镇痛。但其确切的作用效果及其作用机制却未见研究报道。通过多年的研究。

Promethazine, one of histaminergic Hi-receptor antagonist, was often used as an adjuvant drug prior to and during acupuncture anesthesia in clinics, how- ever, its effects was not known clearly. By using potassium iontophoretic dolorimetry and stimulating unilateral 'Hegu' and 'Waiguan' points with electroacupuncture (EA) in 42 rabbits, we found that Promethazine could drop the pain threshold in small dosages (0.5mg/kg, lmg/kg) and raise the pain threshold in relatively large dosages (2mg/kg, 4mg/kg). In different dosages (1mg/kg, 2mg/kg), promethazine could attenuate the analgesic effect of EA. It was suggested that promethazine should beused carefully in acupuncture anaesthesia.