云南省某铅锌矿企业227例尿铅超标患者驱铅治疗疗效评价

Curative effect evaluation of removing lead treatment on 227 employees with excessive lead in urine of a lead and zinc mine enterprise a mine enterprise's whose plumbum in urine are over standard

目的评估云南省某铅锌矿作业工人尿铅超标者的临床诊断类型,探讨在治疗过程中血铅(PbB)、尿铅(PbU)、红细胞锌原卟啉(ZPP)浓度变化规律,评价驱铅治疗的效果。方法治疗结束后,依据《职业性慢性铅中毒诊断标准》(GBZ 37-2002)进行集体诊断。统计驱铅治疗过程中PbB、PbU、ZPP的值,对数据进行t检验和χ2检验,并对两变量相关性进行直线回归分析。结果 227例尿铅超标者诊断为铅中毒临床观察对象、轻度铅中毒、中度铅中毒的百分率分别为3.07%、2.71%、0.13%;驱铅治疗临床观察对象平均治疗1.92个疗程,轻度铅中毒平均治疗2.76个疗程,中度铅中毒平均治疗3.80个疗程后能达到较为满意的效果。结论该矿企尿铅超标的工人驱铅治疗效果良好。

[Objective]To evaluate the clinical diagnosis type of the employees with excessive lead in urine of a lead and zinc mine enterprise,to investigate the concentration variation of plumbum in blood（PbB）,plumbum in urine（PbU）,erythrocyte zinc protoporphyrin（ZPP） in the treating process,and evaluate the effect of removing lead treatment. [Methods]After the treatment,according to ＂Diagnostic Criteria of Occupational Chronic Plumbum Poisoning＂（GBZ 37-2002）,the collective diagnosis was conducted.The value of PbB,PbU,ZPP in the process of removing lead treatment was collected.The t test and χ2 test were adopted for data analysis,and 2 variables related to linear regression analysis was performed. [Results]Of the 227 employees with excessive lead in urine,the percentage of lead poisoning observation objects in clinic,mild lead poisoning,moderate lead poisoning was 3.07%,2.71%,0.13% respectively.The clinical observation objects received 1.92 treatment courses in average,2.76 courses of the mild lead poisoning,3.80 of the moderate lead poisoning,respectively.After the course of treatment,satisfactory curative effect could be obtained. [Conclusion]The curative effect of removing lead treatment is satisfied among employees with excessive lead in urine in this enterprise.