支原体肺炎患儿免疫功能检测及分析

Measurement and analysis of the immunity functions in children with mycoplasma pneumonia

目的:探讨支原体肺炎(MPP)患儿细胞及体液免疫状况,为临床及时有效地对MPP患儿免疫治疗提供理论依据。方法:将140例肺炎患儿分为支原体肺炎组80例、细菌性肺炎组60例,选取同期门诊体检正常小儿42例作为正常对照组,采用流式细胞术和免疫透射比浊法分别检测三组儿童的T细胞亚群、免疫球蛋白IgG、IgA、IgM及补体C3、C4。结果:CD3+、CD4+、CD4+/CD8+比值及补体C3明显低于正常对照组(P<0.01),免疫球蛋白IgG、IgA、IgM、补体C4及CD8+与正常对照组相比,差别无统计学意义(P>0.05)。结论:MPP患儿T淋巴细胞亚群功能失调,细胞免疫功能处于明显低下状态,而免疫球蛋白水平与正常对照儿童比较差别无统计学意义,在常规治疗同时,使用调节机体细胞免疫功能的药物,提高患儿机体细胞免疫功能对MPP的防治具有重要的临床意义。

Objective：To observe the changes of inmmunity functions in children with mycoplasma pneumonia, so as to provide evidence for timely and effective clinical immunotherapy for children with MPP. Methods： The T cell subset, immunoglobulin and complement were detected in 80 children with mycoplasma pneumonia, 60 children with bacterial pneumonia and 42 normal children respectively. Results： The cellular immunity function was in a low state in children with mycoplasma pneumonia, mainly showing a decreased percentage of CDj T lymphocyte, CD4＋ T lymphocyte and a decreased ratio of CD4/CD8＋ （P 〈 0.01 ）. Immunoglobulin, C4, CD8 ＋ showed no significant difference in the three groups, while C3 showed decreased level in the three groups （P 〉 0.05）. Conclusion： Cellular immunity in children with MPP is obviously low. T lymphocyte subpopulation function is imbalance. Complement system has been activated. Raising cellular immunity function has an important significance to orevent and treat MPP.