人乳头瘤病毒基因型在宫颈癌及癌前病变中的分布

Distribution of human papilloma virus genotypes in cervical cancer and precancerosis

目的:了解丽水地区人乳头瘤病毒(HPV)基因型在宫颈癌及癌前病变中的分布。方法:采用HPV分型基因芯片检测系统对68例宫颈癌、62例宫颈上皮内瘤变患者进行HPV基因分型检测,以100例子宫颈炎患者的HPV基因型别作为参照。结果:子宫颈炎、宫颈上皮内瘤变和宫颈癌中HPV检出率分别为75.0%、84.0%和95.5%,其间差异比有显著性。在宫颈癌及癌前病变中,主要基因型分别为HPV16,58,53,52,68和18。结论:丽水市及周边地区宫颈癌及宫颈上皮内瘤变中HPV感染率很高,以16、58、53、52和68型最为常见。

Objective：To investigate distribution of human papilloma virus （HPV） genotypes in cervical cancer and precancerosis. Methods： HPV genotyping chip system were used to identify HPV genotypes in 68 cervical cancer patients and 62 cervical intraepithelial neoplasis （CIN） patients,HPV genotypes of 100 eervicitis patients were taken as a reference. Results： The HPV infection rates in eervicitis, CIN and cervical cancer were 75.0%, 84.0% and 95.5% respectively, which had significant difference. The main genotypes were HPV16, 58, 53, 52, 68 and 18. Conclusion： HPV16, 58, 53, 68 and 52 are the most common genotypes in cervical cancer and cervical intraepithelial neoplasia in Lishui city.