鲍曼不动杆菌的临床分布与耐药性分析

Analysis of clinical distribution and antibiotic resistance of acinetobacter baumanii

目的了解鲍曼不动杆菌的临床分布及其对常用抗生素的耐药情况,为临床感染的预防和治疗提供参考。方法对2008年1月～2010年12月分离的鲍曼不动杆菌的标本来源和科室分布进行分析,统计其对17种常用抗菌药物的耐药率。结果鲍曼不动杆菌最常分离自痰标本,占79.2%,其次是分泌物和尿液。病区分布广泛,以重症监护病房(ICU)最多。该菌对多种抗生素耐药现象严重,对含酶抑制剂复合物和亚胺培南耐药率相对较低,但耐药率均呈逐年上升的趋势。结论鲍曼不动杆菌主要引起呼吸道感染,且多重耐药严重,应引起临床高度重视。

Objective To investigate the clinical distribution and antibiotic resistance of acinetobacter baumanii and provide reference for infection prevention and therapy. Methods All of the acinetobacter baumanii strains isolated from clinical specimens fl;om 2008 to 2010 were collected. The source and distribution of tile specimens were analyzed, and the resistance rates to 17 kinds of antibiotics were detected. Results Most of the 259 strains of acinetobacter baumanii were isolated from sputum （79.2%）, followed by secretion and urine. The majority were distributed in ICU. The resistance of acinetobacter baumanii to most dnlgs was obvious, while its resistance rate to carbapenems and b-lactam/b-lactamase inhibitor combinations was low. But there still was an increasing resistance tendency to them. Conclusion Acinetobacter baumanii is a common pathogen of respiratory tract infection, which has a very high resistance rate to many current clinical antibiotics. Therefore, more attention should be paid to it by physicians.