雷贝拉唑、左氧氟沙星联合呋喃唑酮根除幽门螺杆菌感染

Efficacy and safety of rabeprazole combined with levofloxacin and furazolidone in eradication of helicobacter pylori infection

目的探讨雷贝拉唑、左氧氟沙星联合呋喃唑酮三联方案根除幽门螺杆菌(HP)的疗效及安全性。方法选择158例符合条件的HP阳性慢性胃炎和消化性溃疡患者,随机分为2组:治疗组采用雷贝拉唑(10 mg,2次/d)、左氧氟沙星(200 mg,2次/d)联合呋喃唑酮(100 mg,2次/d),治疗7 d;之后溃疡患者继续服用雷贝拉唑10 mg,1次/d,共3周;对照组采用雷贝拉唑(10 mg,2次/d)、阿莫西林(1 000 mg,2次/d)联合克拉霉素(500 mg,2次/d),治疗7d;之后溃疡患者维持治疗同治疗组;疗程结束4周后复查,观察症状缓解率、溃疡愈合率、HP根除率及不良反应等。结果治疗组和对照组症状缓解率、溃疡愈合率及不良反应分别为91.9%(68/74)、89.7%(35/39)、8.1%(6/74)和90.1%(64/71)、88.1%(37/42)、7.0%(5/71),2组比较差异无统计学意义(P>0.05)。治疗组与对照组HP根除率分别为90.5%(67/74)、71.8%(51/71),治疗组明显高于对照组(P<0.01)。结论雷贝拉唑、左氧氟沙星联合呋喃唑酮三联方案根除幽门螺杆菌具有疗效好、不良反应少等特点,可作为根除幽门螺杆菌的治疗方案之一。

Objective To investigate the efficacy and safety of rabeprazole combined with levofloxacin and furazolidone in eradication of helicobacter pylori （Hp） itffection. Methods 158 patients with chronic gastritis or peptic ulcer with Hp infec- tion were divided into two groups at random. The treatment group was treated by rabeprazole （10mg,bid） combined with levo- floxacin （ 200rag, bid） and furazolidone （ 100mg, bid） for 7 days. The patients with peptic ulcer were given rabeprazole （ 10rag, qd） for 3 wks after the 7th day. The control group was given rabeprazole （10mg,bid） combined with amoxicillin （ 1000rag, bid） and clarithromyein（500mg,bid） for 7 days. The patients with peptic ulcer were administered the same as the treatment group after the 7th day. Tile symptomatic relief rate, ulcer concrescence rate, eradication rate of Hp and adverse reactions were recorded 4 weeks after the treatment course terminated. Results The symptomatic relief rate,ulcer concrescence rate and ad- verse reactions of the treatment group and control group were 91.9% （ 68/74）, 89.7% （ 35/39 ）, 8.1% （ 6/74 ） and 90.1% （64/71）, 88. 1% （37/42）, 7.0% （5/71） respectively. There wasn＇t significant difference between the two groups （P 〉 0. 05 ）. However, the eradication rate was 90.5% （67/74） and 71.8% （ 51/71 ） respectively. The treatment group was higher than the control group （ P 〈 0.01 ）. Conclusion Rabeprazole combined with levofloxacin and furazolidon triple therapy for Hp infection is effective and has smaller adverse effect. It is worth to be recommended as one of the treatments ＇for Hp infection.