黏蛋白(MUC1)在正常贲门上皮、贲门肠化及贲门癌中的表达

The Comparison of MUC1 Expression in Normal Cardia Epithelium,Intestinal Metaplasia and Cardia Adenocarcinoma

目的通过对人贲门肠化(CIM)及贲门癌(CA)标本进行黏蛋白(MUC1)的检测,揭示MUC1在CIM和CA发生发展中的作用及其临床意义。方法经胃镜、病理确诊的CIM 50例取其黏膜作为CIM组;取胃镜活检或手术切除经病理确诊的CA标本50例作为CA组;取正常贲门黏膜20例作为正常对照组。进行免疫组化染色观察各组标本中MUC1的表达情况,并进行组间比较。结果①CIM组MUC1的表达低于CA组(P<0.01)。②MUC1的表达与CA的淋巴结转移、病理学分期呈正相关(P<0.05)。结论 MUC1的表达变化可能与CIM和CA的发生发展密切相关,MUC1与CA的某些临床病理因素相关。监测MUC1可能为CA的诊疗预后提供参考价值。

Objective The incidence of cardia adenocarcinoma（CA） arises greatly over the last 3 decades.Cardia intesinal metaplasia（CIM） are respectively the pathological changes before the cancer of CA.Mucins（MUC1） is one of the important tumor marker.The aim of this study was to discover the role of MUC1 in the pathogenesis of CIM and CA.Methods The expression of MUC1 protein were investigated in normal cardia epithelium（n=20）,CIM（n=50）,and CA（n=50） by using immunohistochemical staining respectively.The differences among the groups were compared.Results ① An increasing intendency of the MUC1 expression level was observed from normal cardia epithelium to CIM and CA.There was a statistically difference in MUC1 expression（P0.01） between CIM and CA.② There was significant correlation between the expression of MUC and cell difference of CA or lymphatic spread or pathologic mage in CA（P0.05）.Conclusion There may be close relation between the expressions of MUC1 and the development from CIM to CA.There is correlation between the expression of MUC and some clinical or pathological factors of CA.Monitoring of MUC may provide valuable information for the diagnosis,treatment and prognosis of CA.