凯纷对妇科恶性肿瘤患者术后曲马多镇痛的影响

Effect of Kaifun on Analgesia Efficacy During PCIA with Tramadol in Patients Undergoing Gynecologic Malignancy Operations

目的研究凯纷用于妇科恶性肿瘤腹腔镜手术时超前镇痛的作用效果。方法 50例妇科宫颈癌或内膜癌的患者随机分为两组,每组25例。Ⅰ组在手术开始前10 min静脉缓注凯纷50 mg,手术中肿瘤切除后再静脉缓注凯纷50 mg;Ⅱ组分别在Ⅰ组相同的时间缓注生理盐水10 mL,分别记录术后1、2、8、24 h的视觉模拟评分。24 h曲马多用量和不良反应。结果术后1、2、8、24 h VAS评分Ⅰ组均低于Ⅱ组(P<0.05),术后24 hⅠ组的曲马多用量(275.8±45.5)mg低于(310.5±57.2)mg(P<0.05),镇痛结束后,两组不良反应中只有恶心呕吐差异有显著意义(P<0.05)。结论凯纷对妇科恶性肿瘤手术的超前镇痛和均衡镇痛,能减少术后曲马多用量,减轻不良反应的发生,提高镇痛质量。

Objective To observe the preemptive analgesia effect of Kaifun on laparoscopic surgery for gynecologic malignancies.Methods The 50 patients with gynecological uterocervical cancer or endometrial cancer were randomly divided into two groups,25 patients in each group.In group Ⅰ,patients received intravenous injection of Kaifun 50 mg slowly at 10 min before surgery and after tumor removal surgery.In group Ⅱ,patients respectively received intravenous injection of saline 10 mL at the same time.The analgesia efficacy of two groups was assessed at 1,2,8,24 h after operation by visual analog scale（VAS）,and 24 h Tramadol dosage and adverse effects were recorded.Results At 1,2,8,24 h after operation,VAS scores in group Ⅰ were lower than those in group Ⅱ（P0.05）;after 24h,Tramadol dosage（275.8±45.5）mg of group Ⅰ was lower than that（310.5±57.2）mg of group Ⅱ（P0.05）.After analgesia there were significant differences between two groups in nausea and vomiting（P0.05）.Conclusion Kaifun can produce preemptive analgesia and balanced analgesia for gynecological malignancies,reduce postoperative Tramadol consumption,reduce the incidence of adverse reactions and improve the quality of analgesia.