期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

喉癌组织中CD_(44)v5、CD_(44)v6蛋白的表达变化及意义

下载PDF
导出
摘要 目的观察喉癌组织中细胞黏附分子CD44v5、CD44v6的表达变化,并探讨其临床意义。方法分别采用免疫组化SP法检测78例喉癌(观察组)及14例癌旁正常组织(对照组)中的CD44v5、CD44v6蛋白。结果观察组CD44v5、CD44v6蛋白阳性52、55例,对照组分别为4、0例;两组比较,P均<0.05。CD44v5、CD44v6蛋白表达与喉癌的TNM分期、组织分化程度及淋巴结转移有关(P均<0.05)。结论喉癌组织中CD44v5、CD44v6蛋白表达增加,两者可作为喉癌转移及预后评估的生物学指标。
作者 梁佳 谷京城
机构地区 辽宁医学院 辽宁医学院附属第一医院
出处 《山东医药》 CAS 2012年第2期100-101,共2页 Shandong Medical Journal
基金 辽宁省科学技术计划立项课题(2009225010-39)
关键词 细胞黏附分子 CD44v5基因 CD44V6基因 鳞状细胞癌 喉肿瘤
分类号 R739.65 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Liotta LA, Stetler-Stevenson WG. Tumor invasion and matastasis: an imbalance of positive and negative regulation [ J]. Cancer Res, 1991,51 (18) :5054-5059.
  • 2郑核,钟德玝,苗雄鹰.CD44v5、CD44v6在胆囊癌组织中的表达研究[J].中国现代手术学杂志,2006,10(3):189-192. 被引量：5
  • 3Chen Y J,Ten C C.Rule combination in a fuzzy neural network. Fuzzy Sets and Systems, 1996;(82)
  • 4Yuan A,Zhang H.A genetic algorithm for generating fuzzy classification rules. Fuzzy Sets and Systems, 1996; (84)
  • 5Pedrycz W.An identification algorithm in fuzzy relational systems. Fuzzy Sets and Systems, 1984; (3)
  • 6Wang L,Mendel J M.Generating fuzzy rules by learning from examples.IEEE Trans Systems Man Cybernet,1992; (22)
  • 7Sugeno M,Yasukawa T.A fuzzy-logic-based approach to qualitative modeling. IEEE Trans Fuzzy Systems, 1993;(1 )
  • 8Satio H, Tsujitani S, Katano K, et al. Serum concentration of CD44 variant 6 and its relation to prognosis in patients with gastric cancer [J]. Cancer, 1998,83(6):1094.
  • 9Levy I, Ovadia B, Erez E, et al. Nosoeomial infections after cardiac surgery in infants and children: incidence and risk factors [ J ]. J Hosp Infect,2003,53 (2) : 111-116.

二级参考文献9

  • 1Shimizu M,Saitoh Y,Itoh H.Immunohistochemical staining of Haras oncogene product in normal,benign,and maligant human pancreatic tissues[J].Hum Pathol,1990,21(6):607-612.
  • 2Stamenkovic I,Amiot M,Pesando JM,et al.A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family[J].Cell,1989,56(6):1057-1062.
  • 3Lee LN,Kuo SH,Lee YC,et al.CD44 splicing pattern is associated with disease progression in pulmonary adenocarcinoma[J].J Formos Med Assoc,2005,104(8):541-548.
  • 4Makrydimas G,Zagorianakou N,Zagorianakou P,et al.CD44 family and gynaecological cancer[J].In Vivo,2003,17(6):633-640.
  • 5Yanagisawa N,Mikami T,Mitomi H,et al.CD44 variant overexpression in gallbladder carcinoma associated with tumor dedifferentiation[J].Cancer,2001,91(2):408-416.
  • 6Mitchell BS,Whitehouse A,Prehm P,et al.CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation[J].Clin Exp Metastasis,1996,14(2):102-114.
  • 7Ashida K,Terada T,Kitamura Y,et al.Expression of E-cadherin,alpha-catenin,beta-catenin,and CD44(standard and variant isoforms) in human cholangiocarcinoma:an immunohistochemical study[J].Hepatology,1998,27(4):974-982.
  • 8Seiter S,Arch R,Rever S,et al.Prevention of tumor metastasis formation by antivariant CD44.Exp Med,1993,177(2):442-455.
  • 9Radotra B,McCormick D.Glioma invasion in vitro is mediated by CD44 hyaluronan interactions[J].J Pathol,1997,181(4):434-438.

共引文献5

山东医药
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部