摘要
清除HIV-1的一个重要的障碍就是在HIV感染的过程中,病毒能够潜伏在某个亚群的细胞中。这些亚群细胞的易感性、生命周期、繁殖能力及其在细胞生理和免疫条件改变的情况下周期性产生病毒的能力对病毒的持续存在都是很重要的影响因素。记忆性CD4+T淋巴细胞、骨髓来源的单核-巨噬细胞及造血祖细胞都被认为是HIV-1前病毒DNA的储藏库。本文对HIV-1持续存在有意义的细胞及清除这些潜伏感染细胞可能的策略进行综述。
A major obstacle in HIV-1 eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects.The susceptibility of cell subpopulations to HIV-1,their life span,their proliferative capacity,and their ability to perio-dically produce infectious virus subsequent to alterations in cellular physiological and/or immunologic changes are critical factors which determine the contribution of these cells to viral persistence.Memory CD4＋ T lymphocytes,bone marrow-derived monocyte-macrophage lineage cells and hematopoietic progenitor cells are considered to be the cell reservoirs of HIV-1.This paper focuses on cell populations contributed to HIV-1 persistence,as well as the possible strategies for eliminating these latently infected cells.
出处
《传染病信息》
2011年第6期380-384,共5页
Infectious Disease Information
基金
国家"十二五"科技重大专项(2012ZX10001-003)
