CT灌注成像在胰腺肿瘤诊断中的应用价值

CT perfusion imaging in the diagnosis of pancreatic tumor

目的:探讨胰腺肿瘤的CT灌注成像(CTPI)特征,评价CTPI在胰腺肿瘤诊断中的价值。方法:对50例胰腺肿瘤患者和45例非胰腺疾病患者行CTPI,选择获得良好灌注图像者共76例,其中胰腺肿瘤患者44例和非胰腺病变患者32例。测量ROI的血流量(BF)、血容量(BV)、达峰时间(TTP)和表面通透性(PS)的值,并进行统计学分析。结果:胰腺癌组织的BF、BV、PS较正常胰腺组织明显减低,TTP较正常胰腺组织升高,差异均有统计学意义。实性假乳头状肿瘤组织的BF、BV、PS较正常胰腺组织明显减低,差异有统计学意义。胰岛细胞瘤的BF、BV较正常胰腺组织明显增高,差异有统计学意义。结论:CTPI可反映胰腺肿瘤的血流动力学特征,对胰腺肿瘤的临床诊断及鉴别诊断有重要的作用。

Objective：To investigate perfusion characteristics of pancreatic tumors by using CT perfusion imaging（CTPI） and to evaluate the clinical value of CTPI in the diagnosis of pancreatic tumors.Methods： 45 patients with normal pancreas and 50 patients with pancreatic tumors underwent CTPI.The sharp images of CTPI including 44 patients with pancreatic tumors and 32 patients with normal pancreas were chosen.The mean blood flow（BF）,blood volume（BV）,time to peak（TTP） and permeability surface area product（PS） was measured and statistically analyzed.Results：Comparing with the normal pancreas,pancreatic carcinoma had lower BF,BV,PS and higher TTP and showed statistical differences（P0.05）.Comparing with the normal pancreas,solid-pseudopapillary tumor of pancreas had lower BF,BV and PS and showed statistical differences（P0.05）.Comparing with the normal pancreas,islet cell tumor had higher BF and BV and showed statistical differences（P0.05）.Conclusion：CTPI can reflect the dynamic blood flow characteristics of pancreatic tumor,which is helpful for the clinical diagnosis and differential diagnosis of pancreatic tumor.