远航人员干眼症的干预效果观察

Observation on effects of intervention in dry eye patients among the prolonged deployed personnel at sea

目的 通过对远航人员干眼症患者进行干预,观察对干眼症患者泪膜不稳定和眼表面损害的治疗效果,为我军今后进行远航训练和护航任务期间防治干眼症提供参考.方法 采用前瞻性研究,以参加“和谐使命-2010”任务的远航人员中确诊的干眼症患者84人作为研究对象,经知情同意分为干预组和非干预组,每组42人.依托866医院船诊治平台进行干预和观察,观察指标包括干预前,干预后7、14、28 d泪膜破裂时间（BUT）、角膜荧光素染色（FL）评分、基础泪液分泌试验（ST）结果,比较干预前后的差异以及干预组和非干预组间的差异.结果 干预7d后干眼症状明显改善,干预前后及干预组和非干预组间比较差异均有统计学意义（P＜0.05）,干预组干预前的BUT、ST和FL评分分别为（5.62±1.61）s、（6.00±1.61 ）mm、（3.43 ±0.86）分,干预后第7天分别为（6.12±1.53）s、（6.64±1.19）mm、（3.77±0.66）分.结论 对远航人员中的干眼症患者进行有效干预,对保证远航人员的眼部健康和提高工作效率具有重要的意义.

Objective To observe the therapeutic effects of intervention （drug and nondrug） on the instability of tear membrane and the disorder of corneal epithelium among the prolonged deployed personnel at sea.Basic experience could also be provided for the prevention and treatment of dry eye in future prolonged sea deployment training and for the implementation of convoy missions.Methods Our research is a prospective study,which uses 84 confirmed dry eye patients as research subjects who participated in the ＂ Mission Harmony-2010＂.The patients were divided into 2 groups on voluntary basis： the intervened group and the nonintervened group,each consisting of 42.Intervention and observation were made by using the Navy hospital ship （No.866） as the medical platform.Symptoms of dry eye,tear break-up time （BUT）,fluorescent bangle staining of cornea （ FL）,and the Schirmer test （ST） were performed before intervention and 7,14 and 28 days after intervention.Comparisons were made to see the differences between pre and post intervention,and also between the intervention group and the non-intervention group.Results Symptoms of dry eye in the intervened group improved obviously,7 days after intervention,and statistical significance could clearly be seen between pre and post intervention,and also between the intervention group and the non-intervention group （ P 〈 0.05 ）.For instance,the levels of BUT,ST and FL in the intervened group pre and post intervention were（5.62 ± 1.61 ） s、（ 6.00 ± 1.61 ） mm and （ 3.43 ± 0.86） score,respectively.Conclusions Effective intervention in dry eye patients was of great significance to the health of eyes and working efficiency of the prolonged deployed personnel at sea.