高压氧暴露对急性脑梗死患者血清S-100B蛋白含量的影响

Effects of HBO on the content of serum S-100B protein in patients with acute cerebral infarction

目的探讨高压氧（HBO）暴露对急性脑梗死患者血清S-100B蛋白含量的影响，并评价HBO的治疗作用。方法应用颅脑MRI／MRA扫描120例急性脑梗死患者，计算脑梗死体积。按照治疗方法分成HBO组（n=56）与对照组（n=64），并采用ELISA法检测2组患者于入院后24、48、72、96h血清S-100B蛋白含量的变化。结果急性脑梗死患者血清S-100B蛋白含量在入院72h后达到顶峰，S-100B蛋白含量与脑梗死体积呈正相关（P〈0．05），HBO组入院后72h时血清S-100B蛋白含量[小梗死：（0．71±0．25）μg／L，中梗死：（1．22±0．37）μg／L]较对照组相同时点[小梗死：（1．26±0．36）μg/L，中梗死：（2．02±0．72）μg／L]明显下降，差异有统计学意义（P〈0．01或P〈0．05）。结论相同时点中S-100B蛋白含量与急性脑梗死体积密切相关，可能对进展性脑卒中有预测作用；临床早期HBO治疗可以降低S-100B蛋白含量，对提高急性脑梗死患者疗效有一定的作用。

Objective To investigate the effects of HBO on the content of resum S-100B protein in patients with acute cerebral infarction and also to evaluate the effect of HBO therapy. Methods One hundred and twenty cases of acute cerebral infarction were scanned with MRI/MRA to measure the size of cerebral infarction. The patients were divided into the HBO group （n = 56 ） and the control group （n = 64 ）, depending on the method of the treatment they received. The changes of the content of serum S-100B protein for the patients of both groups were detected with ELISA at 24,48,72,96 h respectively after admission imto hosfoital. Results The expression of serum S-100B protein reached peak at 72 h after the patients imto hospital. The content of S-100B protein was directly correlated with the size of cerebral infarction （ P 〈 0.01 or P 〈 0.05 ）. The decrease of the contents of S-100B protein [ small infarction： （0.71 ± 0. 25 ） μg/L, middle infarction： （1.22 ±0.37 ）μg/L] in the HBO group was more significant, when compared with those in the control group [ small infarction： （ 1.26 ±0.36 ） μg/L, middle infarction ： （ 2.02 ± 0.72 ） μg/L ], with statistical significance （ P 〈 0.01 or P 〈 0.05 ）. Conclusions The level of serum S-100B protein was closely correlated with the size of cerebral infarction, which might be a good precursor for the prediction of progressive cerebral stroke. Early clinical HBO therapy could decrease S-100B and had some effect on the treatment of patients with acute cerebral infarction.