摘要
Ghrelin是一种由28个氨基酸组成的多肽,是生长激素促分泌素受体的内源性配体。近年来研究显示心力衰竭时ghrelin及其受体的表达及功能发生变化;Ghrelin除具有促进生长激素分泌的作用外,还具有抑制心肌细胞凋亡、抑制心室重构、增强心肌收缩力、直接保护心肌、改善心肌能量代谢、改善心功能、延缓心源性恶病质的生物学效应。这就提示ghrelin可能从上述多方面发挥抗心力衰竭的作用,具有治疗心力衰竭的潜在功效。
Ghrelin,a 28-amino-acid peptide,is an endogenous ligand for the growth hormone secretogogue receptor（GHS-R）.It has been shown that the expression and function of ghrelin and its receptor change in heart failure.In addition to promoting growth hormone secretion,ghrelin has direct positive inotropic effect on cardiomyocytes,inhibit the apoptosis of cardiomyocytes and ventricular remodeling,protect myocardium directly,improve the disturbed myocardial energy metabolism and cardiac function,and attenuate the development of cardiac cachexia.It is suggested that ghrelin may have potential effects on the treatment of heart failure.
出处
《中华老年多器官疾病杂志》
2011年第6期553-555,共3页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
国家自然科学基金(30871066)~~
