肠脂肪酸结合蛋白在缺血性肠病中的研究进展

Role of intestinal fatty acid binding protein in ischemic bowel disease

近年来随着社会人口的日益老龄化,动脉硬化所致的疾病发病率增加,缺血性肠病的患病率也有所增加。由于临床症状不典型,缺血性肠病的误诊率、漏诊率较高,关于缺血性肠病的早期诊断手段尚在研究中。肠脂肪酸结合蛋白富含于小肠粘膜组织中,具有以下特点:(1)存在于胞浆中的可溶性蛋白;(2)具有高组织特异性;(3)组织含量丰富;(4)分子质量低,易于检测。目前肠脂肪酸结合蛋白广泛用于缺血性肠病诊断的研究。本文综述了肠脂肪酸结合蛋白的定义以及作用机制,并且从动物实验和临床实验两方面总结了肠脂肪酸结合蛋白在缺血性肠病诊断中的研究进展。

With the progressive increase of aging population in recent years,the prevalence of ischemic bowel disease induced by arteriosclerosis has strikingly increased.However,this disorder has high rates of missed diagnosis and misdiagnosis because of its atypical clinical symptoms.Therefore,the early diagnosis of ischemic bowel disease needs further research.Intestinal fatty acid binding protein is abundant in small intestinal tissue and has the following characteristics：（1）a soluble protein in the cytoplasm; （2） high tissue specificity;（3） abundance in the tissue;（4） small molecular weight and easy detection.Currently,intestinal fatty acid binding protein is widely used in the research of diagnosis of ischemic bowel disease.In this paper,we summarized the definition and the mechanism through which intestinal fatty acid binding protein play its roles,and the research progress of its role in the diagnosis of ischemic bowel disease in view of animals experiments and clinical research.