沙生蜡菊花降脂活性部位化学成分的分离与鉴定(Ⅱ)

Isolation and identification of chemical constituents in the lipid-lowering fraction of Flos Helichrysum arenarium(Ⅱ)

目的沙生蜡菊花降脂活性部位中的化学成分研究。方法采用硅胶、ODS、制备HPLC等多种色谱方法分离纯化,依据理化性质、波谱数据分析进行结构鉴定。结果从沙生蜡菊花的降脂活性部位中分离得到11个化合物,并分别鉴定为:丁香苷(syringin,1)、二氢丁香苷(dihydrosyringin,2)、(E)-4-hydroxybenzalacetone-3-O-β-D-glucopyranoside(3)、4-烯丙基-2-甲氧基苯基1-O-β-D-呋喃芹糖(1-6)-β-D-吡喃葡萄糖苷[4-allyl-2-methoxyphenyl 1-O-β-D-apiofuranosyl-(1-6)-O-β-D-glu-copyranoside,4]、苔黑酚-β-D-吡喃葡萄糖苷(orcinol-β-D-glucopyranoside,5)、7-hydroxy-5-me-thoxyphthalide-7-O-β-D-glucopyranoside(6)、5,7-dihydroxyphthalide-7-O-β-D-glucopyranoside(7)、undulatoside A(8)、adenosine(9)、maltol-3-O-β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside(10)、2,4,6-三羟基苯乙酮-2,4-二-O-β-D-吡喃葡萄糖苷(2,4,6-trihydroxylacetophenone-2,4-di-O-β-D-glu-copyranoside,11)。结论化合物1～11均为首次从蜡菊属植物中分离得到。

Objective To study the chemical constituents in the lipid-lowering fraction of Flos Helichrysum arenarium. Methods The chemical constituents were isolated by various methods of isolation （ silica gel, ODS and HPLC column chromatography）and their structures were elucidated by the analysis of spectral data and chemical properties. Results Eleven compounds were identified as syringin（ 1 ）, dihydrosyringin（2 ）, （E）-4- hydroxybenzalacetone-3-O-β-D-glucopyranoside （ 3 ）, 4-allyl-2-methoxyphenyl-l-O-β-D-apiofuranosyl-（ 1- 6） -O-β-D-glucopyranoside （ 4 ）, orcinol-β-D-glucopyranoside （ 5 ）, 7-hydroxy-5-methoxyphthalide-7-O-fl-D- glucopyranoside （ 6 ）, 5,7-dihydroxyphthalide-7-O-β-D-glucopyranoside （ 7 ）, undulatoside A （ 8 ）, adenosine （ 9 ）, maltol-3 -O-β-D-apiofuranosyl- （ 1-6 ） -β-D-glucopyranoside （ 10 ）, and 2,4,6-trihydroxylacetoplaenone- 2,4-di-O-fl-D＇-glucopyranoside（11）. Conclusions Compounds 1-11 are obtained from Helichrysum for the first time.