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生物防御用DNA疫苗

DNA vaccines used for biodefense
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摘要 近年的生物防御疫苗研究集中于DNA疫苗。DNA疫苗对人以及环境相对安全、经济，并且多价联合DNA疫苗还可以提供多重保护，因此有良好的研发前景和潜在的实用价值，但也存在免疫原性不强和接种方式有待改进等问题。此文就炭疽杆菌、埃博拉病毒、马尔堡病毒、猴痘病毒、天花病毒和委内瑞拉马脑炎病毒等几种被美国NIH和CDC列为重要生物战剂的DNA疫苗研发现状作一综述。 Most of the recent biodefense work has been focused on developing DNA vaccines, which are safe to both human and environment and cost-effective, and delivery of the combined DNA vaccines can offer the potential for multiple protection. Consequently, the DNA vaccines have good prospects for research, development and applications, but their immunogenicity and delivery methods remain to be improved. This review summarizes the research status of the DNA vaccines against several biodefense pathogens listed on both the NIH priority pathogen and CDC bioterrorism registries： Bacillus anthracis, Ebola and Marburg viruses, monkeypox virus, smallpox virus, and Venezuelan equine encephalitis virus.
作者 刘文宇 朱晓斐 戚中田（综述）
机构地区 第二军医大学微生物学教研室
出处 《国际生物制品学杂志》 CAS 2011年第6期300-303,317,共5页 International Journal of Biologicals
基金 国家传染病重大专项课题（2008ZX10002-013,2009ZX10004-106）
关键词 疫苗 DNA 芽胞杆菌 炭疽 埃博拉病毒 马尔堡病毒 痘病毒科 甲病毒属 生物 防御 Vaccines, DNA Bacillus anthracis Ebola virus Marburg virus Poxviridae Alphavirus Biodefense
分类号 R3 [医药卫生—基础医学]
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参考文献14

  • 1Gu ML, Leppla SH, Klinman DM. Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen [ J]. Vaccine, 1999, 17 (4) : 340-344.
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  • 3Price BM, Liner AL, Park S, et al. Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein [ J ]. Infect Immun, 2001, 69(7 ) :4509-4515.
  • 4Riemenschneider J, Garrison A, Geisbert J, et al. Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus [ J]. Vaccine, 2003, 21 (25/26) :4071-4080.
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  • 6Martin JE, Sullivan NJ, Enama ME, et al. A DNA vaccine for Ebola virus is safe and immunogenic in a phase | clinical trial [ J ]. Clin Vaccine Immunol, 2006, 13 ( 11 ) : 1267-1277.
  • 7Martin JE, Sullivan NJ, Enama ME, et al. A DNA vaccine for Ebola virus is safe and immunogenic in a phase Ⅰ clinical trial [ J ]. Clin Vaccine Immunol, 2006, 13 ( 11 ) : 1267-1277.
  • 8Sakhatskyy P, Wang S, Chou TH, et al. Immunogenicity and protection efi%acy of monovalent and polyvalent poxvirus vaccines that include the D8 antigen [ J ]. Virology, 2006, 355 ( 2 ) : 164-174.
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国际生物制品学杂志
2011年 第6期

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