3项肾小球滤过率内源性标志物的临床应用评价

Clinical evaluation of three different endogenous markers for calculating glomerular filtration rate

目的探讨3项肾小球滤过率内源性标志物的临床应用价值。方法测定57例肾脏疾病患者和50例健康人的血清CystatinC、β2微球蛋白(β2-M)、血清肌酐(Scr)及尿肌酐浓度,计算Ccr值后进行统计分析。结果当肾脏有轻微损伤时,Cys-tatinC出现明显变化,血清β2-M、Scr与健康对照组相比差异无统计学意义;3项肾小球滤过率内源性标志物与Ccr之间均呈高度负相关,血清CystatinC与Ccr相关性的密切程度高于其他两者。结论血清CystatinC的敏感性、特异性优于Scr和血清β2-M,是GFR最理想的内源性标志物,应纳入肾功能常规检查。

Objective To study the clinical significance of three different endogenous markers for calculating glomerular filtration rate（GFR）.Methods 57 cases of patients with kidney diseases and 50 cases of healthy controls were enrolled and determined for serum Cystatin C,β2 microglobulin （β2-M）,creatinine （Scr） and urinary creatinine concentration,then creatinine clearance rate was calculated and statistically analyzed.Results In patients with slight kidney injury,serum Cystatin C level significantly changed,but serum levels of β2-M and Scr showed no difference,when being compared with control group.There were significantly negative correlations between the three endogenous markers for calculating GFR and Ccr level,and serum level of Cystatin C was more correlated with Ccr level than the other two markers.Conclusion The sensitivity and specificity of serum Cystatin C might be superior to Scr and β2-M,could be the most ideal endogenous markers for calculating GFR and should be included in routine examination for renal function.