摘要
目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与川北地区食管癌易感性的关系。方法用PCR-RFLP方法检测食管癌患者100例和同一地区无肿瘤病史的正常对照者97例的MTHFR基因C677T基因型分布。结果 MTHFR C677T呈多态性,可分为3种类型:677CC、677CT、677TT,在食管癌中所占比例分别是37.0%、45.0%、18.0%,对照组分别是41.2%、42.3%、16.5%,两组总构成比差异无统计学意义(=0.829,P>0.05)。结论 MTHFRC677T基因多态性可能与川北地区食管癌的易感性无关。
Objective To investigate the gene polymorphism of methylenetetrahydrofolate reductase(MTHFR)C677T and its association with susceptibility to esophageal cancer(EC) in north Sichuan population.Methods The MTHFR C677T genotypes were detected by a polymerase chain reaction(PCR)-based restriction fragment length polymorphism(RFLP) assay in 100 patients with EC and 97 population cancer-free controls in north Sichuan population.Results The frequencies of MTHFR genotypes,677CC,677CT,677TT were 37.0%、45.0%、18.0% in patients with EC,and 41.2%、42.3%、16.5% in controls respectively,no statistical difrerence between them was found(=0.829,P0.05).Conclusion There may be no relationship between MTHFR C677T polymorphisms and susceptibility of esophageal cancer in north Sichuan population.
出处
《四川医学》
CAS
2012年第1期26-27,共2页
Sichuan Medical Journal
基金
川北医学院自然科学基金(06ZK09)
关键词
亚甲基四氢叶酸还原酶
基因多态性
食管癌
川北地区
methylenetetrahydrofolate reductase
gene polymorphism
esophageal cancer
north Sichuan population