健胃喜食宝片促进消化功能动物试验研究

Animal test on "Jian Wei Xi Shi Bao Tablets" in facilitating digestive function

目的研究健胃喜食宝片促进动物消化功能的效果。方法将昆明种雄性小鼠随机分为空白组、模型对照组和3个剂量(0.53、1.06、1.60g/kgBW)的给药组。各剂量组分别连续经口给予受试样品15d,空白组和模型对照组给予实验用水。用复方地芬诺酯制造小鼠便秘模型,进行小鼠小肠运动试验,测定小鼠的墨汁推进率。将SD雄性大鼠随机分为空白组和3个剂量(0.265、0.53、1.06g/kgBW)的给药组。各剂量组分别连续经口给药30d,观察大鼠体重、体重增重、摄食量和食物利用率,测定大鼠的胃蛋白酶活性和排出量。结果健胃喜食宝片(1.06、1.60g/kgBW)能显著增加小鼠小肠墨汁推进率(P<0.01),能显著增加大鼠体重增重和摄食量,对食物利用率增加不明显。健胃喜食宝片(0.53、1.06g/kgBW)能显著增加大鼠胃蛋白酶活性和胃蛋白酶排出量(P<0.01)。结论健胃喜食宝片具有促进消化功能,即能增进动物食欲和进食量,增加胃液和胃酶分泌量,增加动物体重,增进小肠蠕动;此外还具有润肠通便的功能。

Objective To evaluate the facilitating digestive function of Jian Wei Xi Shi Bao Tablets in animal.Methods Male KM mice were randomly divided into control group,model control group and three dosage groups（0.53,1.06,1.60g/kgBW）.The dosage groups were orally administered respectively with test drugs for 15 days,both control group and model control group were treated with experimental water.Mice constipation model was established by using compound diphenixylate.Small intestine movement was studied out in mice,and the ink propelling rates was detected.Male SD rats were randomly divided into control group and three dosage groups（0.265,0.53,1.06g/kgBW）.The dosage groups were orally administered respectively with test drugs for 30 days.Body weight,weight gain,food intake and food efficiency ratio were observed in rats,and the activity and secretion quantity of pepsin were detected.The control group was treated with experimental water.Results Jian Wei Xi Shi Bao Tablets（1.06,1.60g/kgBW） improved significantly the ink propelling rate in small intestine of mice（P0.01） and the body weight and food intake of rats,with no significant difference in food efficiencyratio.Jian Wei Xi Shi Bao Tablets（0.53、1.06g /kgBW） aslo significantly enhanced the activity and secretion quantity of pepsin in rats（P0.01）.Conclusion The experiment result indicates that ＂Jian Wei Xi Shi Bao Tablets＂has promoting degestive function in animals,namely enhance appetite,food intake,the secretion of gastric juice and pepsin,body weight and small intestine peristalsis,and aslo has the defecation function in mice.