摘要
对白木香Aquilaria sinensis(Lour.)Gilg茎木的化学成分进行研究。应用多种色谱方法进行分离和纯化,波谱技术确定化合物的结构。从白木香茎木中分离并鉴定了13个化合物,分别为爵床脂素A(1),justidin F(2),刺五加酮(3),(+)丁香树脂酚(4),丁香脂双葡萄糖苷(5),无梗五加苷B(6),curuilignan D(7),丁香素(8),4-羟基-3,5-二甲氧基酚苷(9),3,4,5-三甲氧苯基-1-O-β-D-吡喃葡萄糖苷(10),3,4,5-三甲氧苯基-1-O-β-D-呋喃芹糖-(1″→6′)-β-D-吡喃葡萄糖苷(11),7-ketositosterol(12),7-oxo-5,6-dihydrostigmasterol(13)。以上化合物均为首次从沉香属植物中分离得到。
To investigate the chemical constituents of the stems ofAquilaria sinensis (Lour.) Gilg, the separation and purification were performed by solvent extraction, repeated chromatography on silica gel, Sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Thirteen known compounds were isolated and their structures were identified as justicidin A (1), justidin F (2), ciwujiatone (3), (+) syringaresinol (4), syringaresinol-4,4'-di-O-13-D-glucopyranoside (5), syringaresinol-4"O-β-D- glucopyranoside (6), curuilignan D (7), syringin (8), koaburaside (9), 3,4,5-trimethoxyphenyl-l-O-β-D-glucopyranoside (10), 3,4,5-trimethoxyphenyl-l-O-13-D-apiofuranosyl-(1 "→6') glucopyranoside (11), 7-ketositosterol (12), 7-oxo-5,6-dihydrostigmasterol (13). All the compounds described above were isolated from genus Aquilaria for the first time.
作者
陈东
宋月林
聂春晓
马旭
屠鹏飞
Dong Chen;Yue-Lin Song;Chun-Xiao Nie;Xu Ma;Peng-Fei Tu(State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China;Patent Examination Cooperation Center of State Intellectual Property Office,Beijing 100083,China)
基金
The Special Program for New Drug Innovation of the Ministry of Science and Technology,China(Grant No. 2009ZX311-004,2009ZX0308-004)
关键词
白木香
瑞香科
化学成分
木脂素
芳香苷
Aquilaria sinensis
Thymelaeaceae
Chemical constituents
Lignans
Phenolicglycosides