降钙素原对新生儿感染的诊断价值

The value of procalcitonin in diagnosis of neonatal infection

新生儿感染是引起新生儿死亡的重要原因。目前感染检测指标对新生儿感染的诊断在灵敏性、特异性等方面各有差异。近年来，降钙素原（procalcitonin，PCT）被广泛用于各种感染性疾病的诊断，对新生儿感染的早期诊断的灵敏性、特异性均较高，与新生儿感染的严重程度、感染的发展及疾病的预后具有相关性，可用来衡量治疗效果及预后评估。血清PCT在新生儿期不受母体血清PCT水平高低和窒息缺氧损伤引起的急性炎症反应的影响，仅与新生儿自身细菌感染严重程度有关，对新生儿感染的诊断具有特殊意义。

Neonatal infection is one of the important reasons for newborns mortality. The current diagnosis indicators of neonatal infection have differences in the sensitivity and specificity, respectively. In recent years ,procalcitonin（PCT） is widely used in the diagnosis of various infectious diseases. Studies showed that the PCT had higher sensitivity and specificity in the early diagnosis of neonatal infection. Serum PCT level is associated with the severity of neonatal infection, the development and the prognosis of the disease. It can be used to evaluate the effect of treatment and the prognosis. During the period of neonatal, the serum PCT is not affected by the level of maternal and the acute inflammatory response which caused by injuries and asphyxia, and it is associated with the severity of newborn bacterial infection. PCT has special significance to the diagnosis of neonatal infection.