新生儿窒息后急性肾损伤的诊治进展

Progress in diagnosis and treatment of acute kidney injury post neonatal asphyxia

新生儿窒息后急性肾损伤发生率可达56％，易导致多脏器损伤及新生儿死亡。该文综述了近年来国内外窒息后肾损伤的早期诊断生物学标记物、尿蛋白、尿酶、脉冲多普勒超声肾血流检查及治疗的新进展，对新生儿窒息后急性肾损伤的早期诊断、治疗，提高窒息新生儿的存活率、改善预后具有重要意义。

Acute kidney injury（AKI） is a common consequence of perinatal asphyxia, occurring in up to 56% of these infants, which can cause multiply organ dysfunction and neonatal death. This review summaries the development of early detection indexes in laboratory and clinic such as novel biomarker, urinary protein, urinary enzyme, renal blood flow velocity by pulse Doppler ultrasonography, and treatment in AKI post neonatal asphyxia. It provides more positive meanings on early detection, early management and eventually mortality reduction.