静脉滴注维生素K_1致过敏性休克死亡

Death from anaphylactic shock caused by intravenous infusion of vitamin K_1

1例74岁女性患者因咯血入院,给予维生素K1注射液20 mg加入0.9%氯化钠注射液250 ml静脉滴注,滴速40滴/min。输注3 min后,患者出现心慌、胸闷,随即出现呼之不应,叹息样呼吸,呼吸音弱,心率60次/min,血压94/64 mm Hg(1 mm Hg=0.133 kPa)。立即停药,给予地塞米松及肾上腺素,并行吸氧、吸痰治疗。但患者病情无好转,迅即出现呼吸、心搏骤停,血压测不出,心室颤动,最终因抢救无效死亡。

A 74-year-old female patient was admitted to hospital because of hemoptysis and was given an IV infusion of vitamin K1 20 mg in 250 ml of 0.9% sodium chloride at a rate of 40 drops/min.Three minutes after the infusion started,the patient presented with palpitation,chest tightness,no response to voice stimuli,sighing respirations,and decreased breath sounds.Her heart rate was 60 times/min and blood pressure was 94/64 mm Hg.Vitamin K1 was withdrawn and she was treated with dexamethasone,epinephrine,oxygen inhalation and removing sputum by suction.However,her condition did not improve.Subsequently,the patient developed respiratory and cardiac arrest.Her blood pressure was undetectable and ventricular fibrillation occurred.The patient finally died despite resuscitation attempts.