4-哌嗪基-6,7-二甲氧基喹唑啉的合成研究

Study on the Synthesis of 6,7-Dimethoxy-4-(piperazin-1-yl)quinazoline

以4,5-二甲氧基-2-氨基苯甲酸为起始原料,经环化、氯化和取代反应合成了4-哌嗪基-6,7-二甲氧基喹唑啉(3),其结构经1H NMR及MS(APCI)表征。分别对中间体1、2和产物3的合成方法进行了探索,结果表明,在优化合成路线下,目标化合物3的总收率为61%。

6,7-Dimethoxy-4-（piperazin-1-yl）quinazoline（3）was prepared from the staring material 2-amino-4,5-dimethoxybenzoic acid through cyclization,chlorination and substitution in an overall yield of 61% under optimized conditions.The structure of compound 3 was characterized with 1H NMR and MS（APCI）.The syntheses of the intermediates 1,2 and the final product 3 were explored.