摘要
以2-氨基-6-乙酰氨基-4,5,6,7-四氢苯并噻唑氢溴酸盐为原料,经过水解反应除去乙酰基,然后用L(+)酒石酸成盐、解析拆分后合成了制备普拉克索的重要中间体-(-)-(6S)2,6-二氨基-4,5,6,7-四氢苯并噻唑,总收率>75%,并对合成产物进行1H NMR、IR表征分析。
（-）-（6S）2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,an important chiral intermediate for Pramipexole which is a non-ergoline dopamine agonist,was prepared from 2-amino-6-acetamido-4,5,6,7-tetrahydrobenzothiazole hydrobromide and resolved with L（＋）tartaric acid.The title compound was obtained in an overall yield of 75% and its structure was confirmed with 1H NMR and IR.
出处
《精细化工中间体》
CAS
2011年第6期21-23,共3页
Fine Chemical Intermediates
基金
湖北省高校产学研合作重点项目[鄂教科2009(6)]
关键词
四氢苯并噻唑
手性化合物
水解反应
合成工艺
tetrahydrobenzothiazole
chiral compound
hydrolysis
synthesis process
