摘要
以间甲基苯酚为原料,通过磺化、硝化、水解反应,合成3-甲基-2-硝基苯酚。考察了反应物料配比、反应时间、反应温度对收率的影响。收率为98%。目标化合物的结构经1H NMR确证。改进后的工艺降低了合成成本,简单可行,适合工业化生产。
3-Methyl-2-nitrophenol was prepared from 3-methyl phenol via sulfonation,nitration and hydrolysis in an overall yield of 98%.The influence factors on the yield of the target product were investigated.The structure was characterized with 1H NMR.This improved process can simplify the scale manipulation and reduce the cost.
出处
《精细化工中间体》
CAS
2011年第6期26-27,40,共3页
Fine Chemical Intermediates
