摘要
目的:研究缩醛基毛冬青提取化合物R4对缺血缺氧心肌的保护作用,以便为缩醛基毛冬青提取化合物R4的临床新用途提供实验依据。方法:采用小鼠常压耐缺氧实验、夹闭气管小鼠心电消失时间、垂体后叶素所致大鼠心肌缺血模型及大鼠冠脉结扎所致的心肌缺血模型,观察缩醛基毛冬青提取化合物R4对缺血缺氧心肌的保护作用。结果:缩醛基毛冬青提取化合物R4(1.0、2.0、4.0 mg/kg)均能显著延长小鼠常压耐缺氧条件下的存活时间,延长夹闭气管小鼠心电消失时间,缩醛基毛冬青提取化合物R4(0.75、1.5和3.0 mg/kg)能拮抗垂体后叶素引起的心电图变化,并能明显降低结扎冠脉所致大鼠的心肌梗塞范围。结论:缩醛基毛冬青提取化合物R4对缺血缺氧心肌具有明显保护作用,其效应与剂量呈相关性,其机制可能是通过扩张冠脉,增加心肌的供血供氧而发挥抗心肌缺血的作用。
Objective： To study the protective effects of MDQR4 on myocardial ischemia and myocardial hypoxia,so as to pro-vide experimental data for research on new clinical application of MDQR4.Methods： The survival time of mice under the condition of closed normobaric hypoxia,the disappearance time of electrocardiograph sign caused by clamping the trachea,myocardial ischemia in rat induced by injecting pituitrin and myocardial ischemia in rat induced by ligating the left coronary artery were used to observe the protec-tive effect of MDQR4 on myocardial ischemia and myocardial hypoxia.Results： MDQR4（1.0,2.0,4.0 mg/kg） prolonged the survival time of mice under the condition of closed normobaric hypoxia and prolonged the disappearance time of electrocardiograph sign caused by clamping the trachea.MDQR4（0.75,1.5 and 3.0 mg/kg） also significantly reduced the changes of T wave and J point in phaseⅠECG and phase Ⅱ ECG,and could significantly reduce the incidence rate of pituitrin-induced arrhythmia in rat.Conclusion： MDQR4 can pro-tect the myocardial ischemia and myocardial hypoxia injury.These effects were correlated with dose.Its possible mechanism was to pro-tect myocardial ischemia by dilating the coronary artery and increasing the blood and oxygen supply.
出处
《现代生物医学进展》
CAS
2011年第24期4816-4820,共5页
Progress in Modern Biomedicine
基金
广东省自然科学基金科研课题(10151052005000014)
