Survivin在人非小细胞肺癌中的表达及其与VEGF表达的相关性

Expression of Survivin and its Correlation with VEGF in Non-small Cell Lung Cancer

目的:探讨Survivin在人非小细胞肺癌组织中表达、临床意义及其与VEGF表达的相关性。方法:采用免疫组织化学(Envision二步法)检测Survivin和VEGF在116例肺鳞癌、腺癌组织及15例肺良性病变组织中的表达情况。结果:Survivin、VEGF的阳性率分别为62.1%(72/116)、72.4%(84/116),显著高于肺良性病变组织的0(0/15)、13.3%(2/15);Survivin表达与非小细胞肺癌的低分化(P<0.05)、淋巴结转移呈正相关(P<0.05),与患者预后负相关(P<0.05);VEGF的表达与肺癌组织的分化程度、TNM分期及淋巴结转移均有关(P<0.05);并且Survivin表达与VEGF表达呈正相关(P<0.05)。结论:Survivin有望成为肺癌诊断和基因治疗的新靶点。

Objective： To investigate the expression of survivin and its correlation with VEGF in non-small cell lung cancer.Methods： The expression of survivin and VEGF were examined by using immunohistochemica1 staining（Envision two step method.Results： The positive expression rate of survivin and VEGF in NACLC and BPD was 62.1%（72/116）,72.4 %（84/116）respectively,which was obviously higher than that in BPD.The expression of survivin was associated with the poor differentiation（P0.05） and lymph node metastasis（P0.05） respectively.However,it was negative correlated with the prognosis;The expression of VEGF was associated with the poor differentiation,TNM state and lymph node metastasis of lung cancer respective1y（P0.05）.Besides,The expressions of surviving were corre1ated with VEGF each（P0.05）.Condusion： Survivin gene may be identified as a defining diagnostic marker and a potential therapeutic target.