儿茶酚胺类药物对单甲脒中毒豚鼠的实验治疗研究

Experimental therapy of catecholamine drugs for guinea pigs with monoformamidine poisoning

目的 探讨儿茶酚胺类药物在脒类农药中毒治疗中的作用。方法 用生理多导仪观察多巴胺或 (和 )间羟胺对单甲脒染毒 (30mg/kgip .)豚鼠的治疗作用。 结果 各组豚鼠单甲脒染毒后2h的心率、舒张压和心肌收缩力 (dp/dt最大值 ) :多巴胺治疗组分别为 (186± 18)次 /min、(6 5± 4)mmHg(1kPa=7.5mmHg)和 (374± 47)mmHg/s;间羟胺治疗组分别为 (12 0± 36 )次 /min、(48± 8)mmHg和 (197± 70 ) mmHg/s;联合用药组分别为 (2 5 5± 2 9)次 /min、(82± 4)mmHg和 (6 71± 184)mmHg/s ;单甲脒对照组分别为 (95± 2 2 )次 /min、(33± 9)mmHg和 (172± 92 )mmHg/s。多巴胺治疗组和联合用药组以上指标均明显高于单甲脒对照组 ,差异有显著性 (P <0 .0 5 ) ,多巴胺治疗组豚鼠6h后才出现期前收缩和ST T变化 ,2h后恢复Q T间期 ,减少了死亡 ;间羟胺治疗组有类似作用但较弱 ;联合用药组疗效最好 ,豚鼠未出现期前收缩和ST T变化 ,1/ 2h后恢复Q T间期 ,且无死亡。结论 儿茶酚胺类药物在脒类中毒治疗中具有积极作用 ,建议临床在严密观察下适当应用此类药物。

Objective To study the effects of treatment with drugs on monoformamidine poisoning.Methods Using multi channel physiological recorder to observe the effects of dopamine and aramine on guinea pigs with monoformamidine(30 mg/kg ip.).Results The heart rate,blood pressure,and myocardiac contraction(dp/dt max) after 2 h of monoformamidine poisoning were (186±18)beat/min,(65±4) mm Hg(1 kPa=7.5 mm Hg) and (374±47) mm Hg/s respectively in dopamine group;(120±36) beat/min, (48±8) mm Hg and (197±70) mm Hg/s in aramine group;(255±29)beat/min,(82±4) mm Hg and (671±184) mm Hg/s in dopamine+aramine group;and (95±22)beat/min,(33±9) mm Hg and (172±92) mm Hg/s in monoformamidine control group.The results in dopamine and combined group were significantly different from thosein control group( P <0.05).Moreover,no extra systole and ST T alteration and death occurred in combined group,and the recovery of Q T interval was shorter than the other groups,so dopamine+aramine showed the most efficacious therapeutic effect. Conclusion Catecholamine drugs may have positive effects on clinical treatment for monoformamidine poisoning.