胃肠间质瘤及其转化医学

Gastrointestinal stromal tumors and translational medicine

胃肠间质瘤是近年重新认识并且在治疗上取得较大突破的实体肿瘤类型。从发现其主要的发病机制开始,不久即出现了针对性的治疗药物,成为最早进入"靶向治疗"的肿瘤类型之一,体现了转化医学倡导的从实验室研究成果到临床应用的快速转化。回顾10余年来对该病的认识与诊治过程,本身就是对于肿瘤转化医学这一新兴的医学研究模式极佳的诠释。

Gastrointestinal stromal tumors （GISTs） are the most common mesenchymal tumors of the gastrointestinal tract. Gain-of-function mutations on tyrosine kinase receptor are the keys of oncogenesis in GIST, which become the target of therapy, as well as the mechanism of drug resistance. A decade of progress in clinical management of GIST becomes a model of translational medicine research, which advocates rapid conversion from the laboratory achievement to clinical application.