“赵氏脱疽方”干预AGEs及糖尿病足相关因子的研究

The Research of "Zhao's Prescription" Intervention-AGEs and Related Factors of Diabetic Foot

目的:探讨"赵氏脱疽方"治疗糖尿病足,干预血脂、糖基化终末产物(AGEs)及相关因子的作用。方法:将符合纳入标准的糖尿病足患者39例随机分成3组,各组在给予糖尿病常规治疗基础上,给予纯中药组(13例)口服赵氏脱疽汤,并用赵氏脱疽膏外敷;给予中西药结合组(12例)口服赵氏脱疽汤,并用依沙吖啶外敷;给予纯西药对照组(14例)口服已酮可可碱,并用依沙吖啶外敷。观察各组治疗前后糖化血红蛋白、AGEs等。结果:3组治疗前后有明显变化,各组疗效比较,纯中药组疗效优于中西药结合组,纯中药组和中西药结合组疗效均明显优于西药对照组。结论:中医药治疗糖尿病足坏疽有其独特优势,"赵氏脱疽方"对于AGE及相关因子均有不同程度的改善,同时配合中药外治糖尿病足坏疽有明显优势。

Objective：It is to discuss ＂Zhao＇s Prescription＂intervention-AGEs and related factors to improve the treatment of diabetic foot.Methods： 39 cases of diabetic foot patients were divided into three groups,and each group were given conventional treatment of diabetes.Chinese medicine group（13 cases） is given oral Zhao＇s Prescription soup,and with Zhao＇s Prescription cream;Integrative medicine group（12 cases） is given Zhao＇s Prescription soup,and use topical ethacridine;Comparison group（14 cases）,is given administration of pentoxifylline and topical use ethacridine.we observed the index change of glycosylated hemoglobin,lipids and Advanced glycation end products（AGEs） and so on before and after treatment.Results： There are significant changes before and after treatment in the three groups,.Chinese medicine group is superior to the Integrative medicine group,Chinese medicine group and the Integrative medicine group was significantly better than comparison group.Conclusion：TCM treatment of diabetic foot gangrene has its unique advantages.The results show that ＂Zhao＇s Prescription soup＂ for AGE,blood sugar,blood lipid get improvement in different degrees,and using external traditional Chinese medicine has obvious advantages on curing diabetic foot gangrene