救肾汤治疗肾综合征出血热急性肾功能衰竭50例

Jiushen decoction in the treatment of 50 patients with acute renal failure due to hemorrhagic fever with renal syndrome

目的探讨自拟救肾汤对肾综合征出血热急性肾功能衰竭的治疗作用。方法将98例肾综合征出血热急性肾功能衰竭患者随机分为两组，对照组48例采用西医西药治疗，包括支持治疗、利尿等；观察组50例服采用自拟救肾汤（药物组成：生石膏、知母、玄参、生地黄、金银花、连翘、生栀子、黄芩、丹参、川芎、赤芍等）进行治疗，疗程均为1周。观察两组治疗前后尿量、血尿素氮、出血、肾功能、神志等变化。部分患者进行肾活检。结果治疗后两组症状、体征均有改善，观察组优于对照组（X^2=14．16，P〈0．05）；总有效率观察组（92．0％）优于对照组（60．42％，X^2=18．19，P〈0．01）；观察组组织病理学改变稍优于对照组，但差异无统计学意义。结论救肾汤有较明显的改善微循环、增加肾血流、改善肾功能等作用。

Objective To study the therapeutic effects of self-drafted Jiushen decoction on patients with acute renal failure due to hemorrhagic fever with renal syndrome. Methods Ninty-eight actute renal failure patients were divided into two groups： control group（48 cases） was treated with western medicine, including supportive and diuretic treatment; Treatment group （50 cases） were treated with traditional Chinese medicine of Jiushen decoction （ medicine form ： cypsum, anemarrhena asphodel ides, scrophularia ningpoensis hemsl, rehmannia glutinosa, honeysuckle, forsythia suspense, jasmine, scutellaria barcalensis georgi,salvia mihiorrhiza, ligusticum chuanxiong hort, paeonia veitchii ）. The therapeutic course were 1 week in the two groups. The urine amount and blood plasma carbamide, hemorrhage, kidney function and senses symptoms were observed before and after treatment, and kidney biopsy was performed in part of the patients. Results After treatment,the clinical symptoms and signs were impoved in both groups,but the im-provements in observation group were superior to that in control,group （X^2 = 14. 16, P 〈 0. 05）. Total effective rate in observation group （92. 0% ） was higher than that in control group （60. 42%,X2 = 18. 19, P 〈0. 01） ; The histological changes in observation group were better than that in control group, but there was no significant difference. Conclusions The self-drafted Jiushen decoction has good curative effect for microcirculation, it also can improve the kidney function and increase blood replication.