老年女性骨质疏松症患者骨代谢生化指标的研究

The study on bone biochemical markers in old female patients with osteoporosis

目的分析骨代谢生化指标在老年女性骨质疏松症(OP)临床诊治中的应用价值。方法采用电化学发光法测定73例老年女性OP患者空腹血清中骨钙素(BGP)、总Ⅰ型胶原氨基端延长肽(TPINP)、β-降解序列(β-Cross)、甲状旁腺素(PTH)、1,25(OH)2维生素D3的含量。按年龄段分为两个观察组并与健康对照组的测定值进行的分析。结果老年女性OP患者<70岁(55～<70岁)组和≥70岁(≥70～93岁)组BGP、TPINP、β-Cross、PTH均高于对照组,1,25(OH)2维生素D3均低于对照组;而两观察组间除BGP、β-Cross外,其他各值差异均无统计学意义。<70岁老年女性OP患者血清中骨代谢生化指标具有明显高转换型OP的特征。结论骨代谢生化指标的测定在老年女性OP的诊断和治疗中有一定的应用价值。

Objective To analyze biochemical markers of bone in elderly women with osteoporosis diagnosis and of the application treatment.Methods Serum osteocalcin,total N-terminal extension of type Ⅰ collagen peptide,β-degradation sequence,parathyroid hormone,1,25（OH）2 vitamin D3 contents of 73 cases with osteoporosis were tested by electrochemical luminescence.All the patients were divided into two study groups by age and compared with the control group forstatistical analysis of measured values.Results Osteocalcin,total N-terminal extension of type Ⅰ collagen peptide,β-degradation sequence,parathyroid hormone of elderly women of osteoporosis patients 70 years（55-70 years old）group and ≥70 years（70-93 years old）group were higher and 1,25（OH）2 vitamin D3 of them were lower than the control group.Apart from osteocalcin,β-degradation sequence,the other the values were no significantly different in two study groups.70 years old women with osteoporosis bone metabolic markers in serum had obvious high conversion feature osteoporosis.Conclusion The measured biochemical indicators of bone metabolism in elderly women with osteoporosis are valuable in diagnosis and treatment.