1Zhang Y,Jia Y,Zheng R,et al. Plasma microRNA 122 as a bio marker for viral-, alcohol-, and chemical-related hepatic diseases[J]. Clin Chem,2010,56(12) : 1830-1838.
2Wu FL,Jin WB, I.i JH ,et al. Targels for human encoded microR- NAs in HBV genes[J]. Virus Genes,2011,42(2) : 157 161.
3Zhang GL, Li YX, Zheng SQ, et al. Suppression of hepatilis B vi- rus replication by microRNA-199a-3p and microRNA 210[J]. An tiviral Res,2010,88(2) :169-175.
4Zhang X, Zhang E, Ma Z, et al. Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1[J]. Hepatology, 2011,53(5) :1476-1485.
6Henk JI, Goergen D, Zheng J, et al. microRNA-122 stimulates translation of hepalitis C virus RNA[J]. EMBO J,2008,27(24) : 3300-3310.
7Murakami Y,Aly HH,Tajima A,et al. Regulation of the hepatitis C virus genome replication by miR-199a[J].J Hepatol,2009,50 (3) :453-460.
8Sarasin-Fillipowicz M, Krol J, Markiewicz I, et al. Decreased levels of microRNA-122 in individuals with hepatitis C responding poor ly to interferon therapy[J]. Nat Med, 2009,15 ( 1 ) : 31-33.
9Pedersen IM, Cheng G, Wieland S, et al. Interferon modulation of cellular microRNAs as an antiviral mechanism[J]. Nature, 2007, 449(7164) :919-922.
10Scagnolari C,Zingariello P, Vecchiet J, et al. Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha[J]. Virol J,2010,(7) :311.
3Baranwal S,Alahari SK.miRNA control of tumor cell invasion and metastasis[J].Int J Cancer,2009,126(6):1283-1290.
4Croce CM.Causes and consequences of microRNA dysregulation in cancer[J].Nat Rev Genet,2009,10(10):704-714.
5Garzon R,Calin GA,Croce CM.MicroRNAs in cancer[J].Annu Rev Med,2009,60:167-179.
6Kutay H,Bai S,Datta J,et al.Downregulation of miR-122 in the rodent and human hepatocellular carcinomas[J].J Cell Biochem,2006,99(3):671-678.
7Chang J,Nicolas E,Marks D,et al.MiR-122,a mammalian liver-specific microRNA,is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1[J].RNA Biol,2004,1(2):106-113.
8Wang KR,Yan JX,Zhang BZ,et al.Novel mode of action of polybia-MPI,a novel antimicrobial peptide,in multi-drug resistant leukemic cells[J].Cancer Lett,2009,278(1):65-72.
9Coulouarn C,Factor VM,Andersen JB,et al.Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties[J].Oncogene,2009,28(40):3526-3536.
10Bai S,Nasser MW,Wang B,et al.MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib[J].J Biol Chem,2009,284(46):32015-32027.
2David A B,Sigmund S. Pathogenesis of alcoholic hepatitis[J]. J Gastroenterol Hepato1,2004,19 : $229-$235.
3Ye Q, Lian F, Chavez P R, et al. Cytoehrome P4502E1 inhibition prevents hepatic eareinogenesis induced by diethylnitrosamine in alcohol-fed rats [ J ]. Hepatobiliary Surg Nutr,2012,1:5-18.
4WKK Wu, CH CHo, CW Lee, et al. Dysregulation of cellular signaling in gastric cancer [ J ]. Cancer letters, 2010,295 : 144-153.
5Izu H, Shobayashi M, Manabe Y, et al. Sake yeast sup- presses acute alcohol-induced liver injury in mice [ J ]. Biosci Biotechnol Biochem,2006 ,70 :2488-2493.
6Gerjevic L N, Liu N, Lu S, et al. Alcohol activates TGF- Beta but inhibits BMP receptor-mediated smad signaling and smad4 binding to hepcidin promoter in the liver[J]. Int J Hepato1,2012 :4578-4592.
7Pari L, Karthikesan K. Protective role of caffeie acid against alcohol-induced biochemical changes in rats [ J ]. Fundam Clin Pharmacol,2007,21:355-361.
8Dey A. Cytoehrome p450 2El : Its role in disease and drug metabolism[ M]. Dordrecht, Heidelberg, New York, London : Springer, 2013.