伴微量白蛋白尿的2型糖尿病患者血清唾液酸的变化

Serum Sialic Acid Concentration in Type II Diabetes Mellitus Patients with Microalbuminuria

目的:测定伴或不伴微量白蛋白尿的2型DM患者的血清唾液酸(SA)浓度,以探讨血清SA水平与DM血管病变之间的关系。方法:选75例门诊和住院的2型DM患者,和年龄、性别、体重指数与之相匹配的正常对照者28人。DM患者根据尿白蛋白排泄率分作正常白蛋白尿组和微量白蛋白尿组。测定各组的SA、糖基化血红蛋白、血脂、肌酐。结果:微量白蛋白尿组的SA水平[(631±34)μg/ml]显著高于正常白蛋白尿组[(544±24)μg/ml]和正常对照组,而且正常白蛋白尿组的SA水平亦显著高于正常对照组。结论:血清SA水平增加可能是DM患者心脑血管疾病的危险因子。

Because microalbuminuria can predict the development of renal and cardiovascular disease in diabetics, the serum sialic acid (SA) concentrations were determined to investigate the potential association between serum SA and mi-croangiopathy in type 2 diabetes mellitus (DM) patients. Methods: 39 patients with type 2 DM who had a normal urinary albumin excretion rate,36 patients who had microalbuminuria,and 28 healthy people as control group. They were matched for age,sex and body mass index. Fasting blood samples were taken for measurement of SA, cholesterol, triglyceride, creati-nine and HbA1 c. Results:Serum SA was significantly higher in microalbuminuric patients ,compared with normoalbuminuric patients (631±34)μg/ml vs (544±24)μg/ml. Moreover, serum SA was also significantly higher in normoalbuminuric patients compared with control group (544±24)μg/ml vs (453±29)μg/ml. Conclusion: The observation suggested that the SA concentrations were raised in type 2 diabetics and might play a role as a diabetic microangiopathy risk factor.