血清超敏C反应蛋白、血脂水平与颈动脉斑块和脑梗死的相关性研究

Clinical study on the relationship between serum high sensitivity C-reactive protein,lipids levels and carotid artery plaque and cerebral infarction

目的探讨血清超敏C反应蛋白(hs-CRP)、血脂水平与颈动脉斑块和脑梗死之间的相关性。方法选择56例急性脑梗死(ACI)患者、72例腔隙性脑梗死(LI)患者和40例健康者为对照组,测定其血清hs-CRP、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);ACI组和LI组根据彩色多普勒超声检查分别分为有斑块形成组(ACI-P组,LI-P组)和无斑块形成组(ACI-NP组,LI-NP组),比较其hs-CRP、血脂水平。结果 ACI组hs-CRP、TC水平高于对照组,LDL-C水平高于对照组和LI组;LI组TC水平高于对照组(P<0.05)。与ACI-NP组和LI-NP组比较,hs-CRP在ACI-P组及LI-P组均明显升高,且LI-P组HDL-C降低(P<0.05)。结论血清hs-CRP水平增高及HDL-C水平降低,与颈动脉斑块形成、脑梗死的发生密切相关,应予以监测和及时控制。

Objective To evaluate serum high sensitivity C-reactive protein（hs-CRP）,lipids and the correlation with carotid artery plaque and cerebral infarction.Methods 56 patients with acute cerebral infarction（ACI）,72 patients with lacunar infarction（LI）,40 healthy persons controls,were measured about serum hs-CRP,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）.On color Doppler ultrasound examination ACI group and LI group were subdivided into plaque groups（ACI-P,LI-P） and no plaque groups（ACI-NP,LI-NP）,those of hs-CRP,blood lipid levels were compared.Results ACI group had significantly higher hs-CRP,TC levels than control group,and also had higher LDL-C levels than the other two groups.LI group had higher TC levels than control group（P0.05）.Compared with the ACI-NP,LI-NP groups,hs-CRP of ACI-P,LI-P groups were significantly higher both in the ACI group and LI group,HDL-C decreasing only in the LI-P group（P0.05）.Conclusion The increasing levels of serum hs-CRP and decreasing levels of HDL-C have close relation with the carotid artery plaque and CI formation,must to be monitored and controlled in time.